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Resveratrol and Neu...
Resveratrol and Neuroprotection : Impact and Its Therapeutic Potential in Alzheimer's Disease
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- Rahman, Md. Habibur (author)
- Southeast Univ, Dept Pharm, Dhaka, Bangladesh.
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- Akter, Rokeya (author)
- Jagannath Univ, Dept Pharm, Dhaka, Bangladesh.
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- Bhattacharya, Tanima (author)
- Hubei Univ, Sch Chem & Chem Engn, Wuhan, Peoples R China.
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- Abdel-Daim, Mohamed M. (author)
- King Saud Univ, Dept Zool, Coll Sci, Riyadh, Saudi Arabia.;Suez Canal Univ, Pharmacol Dept, Fac Vet Med, Ismailia, Egypt.
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- Alkahtani, Saad (author)
- King Saud Univ, Dept Zool, Coll Sci, Riyadh, Saudi Arabia.
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- Arafah, Mohammed W. (author)
- King Saud Univ, Dept Zool, Coll Sci, Riyadh, Saudi Arabia.
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- Al-Johani, Norah S. (author)
- King Saud Univ, Dept Zool, Coll Sci, Riyadh, Saudi Arabia.
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- Alhoshani, Norah M. (author)
- King Saud Univ, Dept Zool, Coll Sci, Riyadh, Saudi Arabia.
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- Alkeraishan, Nora (author)
- King Saud Univ, Dept Zool, Coll Sci, Riyadh, Saudi Arabia.
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- Alhenaky, Alhanof (author)
- King Saud Univ, Dept Zool, Coll Sci, Riyadh, Saudi Arabia.
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- Abd-Elkader, Omar H. (author)
- King Saud Univ, Sci Coll, Phys & Astron Dept, Riyadh, Saudi Arabia.
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- El-Seedi, Hesham (author)
- Uppsala universitet,Farmakognosi,Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang, Jiangsu, Peoples R China.;Uppsala Univ, Dept Pharmaceut Biosci, Pharmacognosy Grp, Uppsala, Sweden.
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- Kaushik, Deepak (author)
- Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak, Haryana, India.
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- Mittal, Vineet (author)
- Maharshi Dayanand Univ, Dept Pharmaceut Sci, Rohtak, Haryana, India.
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Southeast Univ, Dept Pharm, Dhaka, Bangladesh Jagannath Univ, Dept Pharm, Dhaka, Bangladesh. (creator_code:org_t)
- 2020-12-30
- 2020
- English.
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In: Frontiers in Pharmacology. - LAUSANNE, SWITZERLAND : Frontiers Media SA. - 1663-9812. ; 11
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Abstract
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- Alzheimer's disease (AD) is a progressive cortex and hippocampal neurodegenerative disease which ultimately causes cognitively impaired decline in patients. The AD pathogen is a very complex process, including aggregation of A beta (beta-amyloid peptides), phosphorylation of tau-proteins, and chronic inflammation. Exactly, resveratrol, a polyphenol present in red wine, and many plants are indicated to show the neuroprotective effect on mechanisms mostly above. Resveratrol plays an important role in promotion of non-amyloidogenic cleavage of the amyloid precursor protein. It also enhances the clearance of amyloid beta-peptides and reduces the damage of neurons. Most experimental research on AD and resveratrol has been performed in many species, both in vitro and in vivo, during the last few years. Nevertheless, resveratrol's effects are restricted by its bioavailability in the reservoir. Therefore, scientists have tried to improve its efficiency by using different methods. This review focuses on recent work done on the cell and animal cultures and also focuses on the neuroprotective molecular mechanisms of resveratrol. It also discusses about the therapeutic potential onto the treatment of AD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Alzheimer's disease
- resveratrol
- oxidative stress
- neuroprotective
- therapeutic agent
- bioavailability
Publication and Content Type
- ref (subject category)
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Rahman, Md. Habi ...
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Akter, Rokeya
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Bhattacharya, Ta ...
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Abdel-Daim, Moha ...
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Alkahtani, Saad
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Arafah, Mohammed ...
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Al-Johani, Norah ...
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Alhoshani, Norah ...
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Alkeraishan, Nor ...
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Alhenaky, Alhano ...
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Abd-Elkader, Oma ...
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El-Seedi, Hesham
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Kaushik, Deepak
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Mittal, Vineet
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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Frontiers in Pha ...
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Uppsala University