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The therapeutic and...
The therapeutic and neuroprotective effects of an antiepileptic drug valproic acid in glioma patients
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- Li, Cong (author)
- Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Peoples R China.;Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
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- Chen, Huijing (author)
- Guangzhou Huashang Vocat Coll, Guangzhou, Peoples R China.
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- Tan, Qijia (author)
- Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Peoples R China.;Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
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- Xie, Caijun (author)
- Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Peoples R China.;Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
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- Zhan, Wengang (author)
- Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Peoples R China.;Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
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- Sharma, Aruna (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Sharma, Hari Shanker (author)
- Uppsala universitet,Anestesiologi och intensivvård
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- Zhang, Zhiqiang (author)
- Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Peoples R China.;Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China.
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Chinese Med Hosp Guangdong Prov, Dept Neurosurg, Guangzhou, Peoples R China;Guangzhou Univ Chinese Med, Affiliated Hosp 2, Guangzhou, Peoples R China. Guangzhou Huashang Vocat Coll, Guangzhou, Peoples R China. (creator_code:org_t)
- ELSEVIER, 2020
- 2020
- English.
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In: Neuropharmacology of Neuroprotection. - : ELSEVIER. - 9780128208137 ; , s. 369-379
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Glioma is the most common primary malignant brain tumor in adults and the patients have poor prognosis despite treatment with surgery, radiotherapy and chemotherapy. The anti-epileptic drug, valproic acid (VPA) as a HDAC inhibitors is often used in glioma patients even if the patients don't have brain tumors associated epilepsy (BAE). Some previous studies have found that VPA not only has anti-epileptic effect, but also has anti-glioma growth effect through enhance radiotherapy sensitivity or other mechanism. Then VPA is reported to improve the survival of glioma patients receiving chemoradiation therapy. In addition, there are limited researches have shown that VPA has a neuroprotective effect in protect normal cells and tissues from the deleterious effects of treatment of glioma, especially radiotherapy. We'll give a brief overview of these effects of VPA in glioma patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Neuroprotective effect
- Glioma
- Valproic acid
Publication and Content Type
- ref (subject category)
- kap (subject category)
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