Search: onr:"swepub:oai:DiVA.org:uu-435702" >
Mild traumatic brai...
Mild traumatic brain injury exacerbates Parkinson's disease induced hemeoxygenase-2 expression and brain pathology : Neuroprotective effects of co-administration of TiO2 nanowired mesenchymal stem cells and cerebrolysin
-
- Sharma, Aruna (author)
- Uppsala universitet,Anestesiologi och intensivvård
-
- Muresanu, Dafin F. (author)
- Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania.;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania.
-
- Castellani, Rudy J. (author)
- Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA.
-
show more...
-
- Nozari, Ala (author)
- Massachusetts Gen Hosp, Anesthesiol & Intens Care, Boston, MA 02114 USA.
-
- Vicente Lafuente, Jose (author)
- Univ Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Bizkaia, Spain.
-
- Sahib, Seaab (author)
- Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.
-
- Tian, Z. Ryan (author)
- Univ Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA.
-
- Buzoianu, Anca D. (author)
- Iuliu Hatieganu Univ Med & Pharm, Dept Clin Pharmacol & Toxicol, Cluj Napoca, Romania.
-
- Patnaik, Ranjana (author)
- Banaras Hindu Univ, Indian Inst Technol, Sch Biomed Engn, Dept Biomat, Varanasi, Uttar Pradesh, India.
-
- Wiklund, Lars (author)
- Uppsala universitet,Anestesiologi och intensivvård
-
- Sharma, Hari Shanker (author)
- Uppsala universitet,Anestesiologi och intensivvård
-
show less...
-
(creator_code:org_t)
- ELSEVIER, 2020
- 2020
- English.
-
In: Neuropharmacology of Neuroprotection. - : ELSEVIER. - 9780128208137 ; , s. 157-231
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Mild traumatic brain injury (mTBI) is one of the leading predisposing factors in the development of Parkinson's disease (PD). Mild or moderate TBI induces rapid production of tau protein and alpha synuclein (ASNC) in the cerebrospinal fluid (CSF) and in several brain areas. Enhanced tau-phosphorylation and ASNC alters the molecular machinery of the brain leading to PD pathology. Recent evidences show upregulation of constitutive isoform of hemeoxygenase (HO-2) in PD patients that correlates well with the brain pathology. mTBI alone induces profound upregulation of HO-2 immunoreactivity. Thus, it would be interesting to explore whether mTBI exacerbates PD pathology in relation to tau, ASNC and HO-2 expression. In addition, whether neurotrophic factors and stem cells known to reduce brain pathology in TBI could induce neuroprotection in PD following mTBI. In this review role of mesenchymal stem cells (MSCs) and cerebrolysin (CBL), a well-balanced composition of several neurotrophic factors and active peptide fragments using nanowired delivery in PD following mTBI is discussed based on our own investigation. Our results show that mTBI induces concussion exacerbates PD pathology and nanowired delivery of MSCs and CBL induces superior neuroprotection. This could be due to reduction in tau, ASNC and HO-2 expression in PD following mTBI, not reported earlier. The functional significance of our findings in relation to clinical strategies is discussed.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Parkinson's disease
- Traumatic brain injury
- Concussive head injury
- Tau
- Alpha synuclein
- Hemeoxygenase-2
- Neuroprotection
- Cerebrolysin
- Mesenchymal stem cells
- Nanowired drug delivery
Publication and Content Type
- ref (subject category)
- kap (subject category)
Find in a library
To the university's database
- By the author/editor
-
Sharma, Aruna
-
Muresanu, Dafin ...
-
Castellani, Rudy ...
-
Nozari, Ala
-
Vicente Lafuente ...
-
Sahib, Seaab
-
show more...
-
Tian, Z. Ryan
-
Buzoianu, Anca D ...
-
Patnaik, Ranjana
-
Wiklund, Lars
-
Sharma, Hari Sha ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Neuropharmacolog ...
- By the university
-
Uppsala University