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Moving genome edited crops forward from the laboratory bench to the kitchen table
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- Hong, Jun (author)
- Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China.
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- Shi, Qian (author)
- Uppsala universitet,Mikrosystemteknik
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- Biswas, Sukumar (author)
- Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China.
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- Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, Joint Int Res Lab Metab & Dev Sci, Shanghai 200240, Peoples R China Mikrosystemteknik (creator_code:org_t)
- Elsevier, 2021
- 2021
- English.
- In: Food Control. - : Elsevier. - 0956-7135 .- 1873-7129. ; 122
- Research review (peer-reviewed)
Abstract
Subject headings
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- Targeted nuclease based genome editing technology particularly clustered regularly interspaced short palindromic repeats (CRISPR) that allows to manipulate virtually almost any genomic sequences has greatly facilitated both basic and applied researches in plants. However, so far, very few of them has entered to the field and much less to the kitchen table. This review starts with a brief summary of current status of the application of genome editing in crop science and crop breeding and, then identifies technical, ethical, intellectual and other challenges for the commercialization of genome edited crops. This review explores further advances in the specificity and the prediction and detection of off-targets of CRISPR system, and highlights the importance of molecular characterization and the introduction of novel techniques such as nanotechnology to CRISPR system. Finally, this review calls for collaborative efforts in proposing principles and guidelines for moving genome edited crops forward from the laboratory bench to the kitchen table, and emphasizes the equal importance of public outreach.
Subject headings
- LANTBRUKSVETENSKAPER -- Bioteknologi med applikationer på växter och djur -- Genetik och förädling inom lantbruksvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agricultural Biotechnology -- Genetics and Breeding in Agricultural Sciences (hsv//eng)
Keyword
- Crop breeding
- Genome editing
- Molecular characterization
- Nanotechnology
- Nature variation
- Off-target
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