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Mesoscopic 3D imagi...
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Hahn, MaxUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Johan Bures Vag 12, S-90187 Umeå, Sweden.
(author)
Mesoscopic 3D imaging of pancreatic cancer and Langerhans islets based on tissue autofluorescence
- Article/chapterEnglish2020
Publisher, publication year, extent ...
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2020-10-26
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NATURE RESEARCH,2020
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-435917
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435917URI
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https://doi.org/10.1038/s41598-020-74616-6DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180639URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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The possibility to assess pancreatic anatomy with microscopic resolution in three dimensions (3D) would significantly add to pathological analyses of disease processes. Pancreatic ductal adenocarcinoma (PDAC) has a bleak prognosis with over 90% of the patients dying within 5 years after diagnosis. Cure can be achieved by surgical resection, but the efficiency remains drearily low. Here we demonstrate a method that without prior immunohistochemical labelling provides insight into the 3D microenvironment and spread of PDAC and premalignant cysts in intact surgical biopsies. The method is based solely on the autofluorescent properties of the investigated tissues using optical projection tomography and/or light-sheet fluorescence microscopy. It does not interfere with subsequent histopathological analysis and may facilitate identification of tumor-free resection margins within hours. We further demonstrate how the developed approach can be used to assess individual volumes and numbers of the islets of Langerhans in unprecedently large biopsies of human pancreatic tissue, thus providing a new means by which remaining islet mass may be assessed in settings of diabetes. Generally, the method may provide a fast approach to provide new anatomical insight into pancreatic pathophysiology.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Nord, ChristofferUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Johan Bures Vag 12, S-90187 Umeå, Sweden.(Swepub:umu)chsv0004
(author)
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Franklin, Oskar,1985-Umeå universitet,Kirurgi,Umeå Univ, Dept Med Biosci, Umeå, Sweden.(Swepub:umu)osfr0002
(author)
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Alanentalo, TomasUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Johan Bures Vag 12, S-90187 Umeå, Sweden.(Swepub:umu)tosalo98
(author)
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Eriksson, MariaUmeå universitet,Patologi,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Dept Med Biosci, Umeå, Sweden.,Umeå Univ, Umeå Ctr Mol Med, Johan Bures Vag 12, S-90187 Umeå, Sweden.(Swepub:umu)maer0057
(author)
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Morini, FedericoUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Johan Bures Vag 12, S-90187 Umeå, Sweden.(Swepub:umu)femo0004
(author)
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Eriksson, MariaUmeå Univ, Umeå Ctr Mol Med, Johan Bures Vag 12, S-90187 Umeå, Sweden.
(author)
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Korsgren, OlleUppsala universitet,Klinisk immunologi(Swepub:uu)ollekors
(author)
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Sund, MalinUmeå universitet,Kirurgi,Department of Surgical and Perioperative Sciences/Surgery, Umeå University Hospital, Umeå, Swede,Umeå Univ, Dept Med Biosci, Umeå, Sweden.;Umeå Univ Hosp, Dept Surg & Perioperat Sci Surg, Umeå, Sweden.(Swepub:umu)masu0021
(author)
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Ahlgren, UlfUmeå universitet,Umeå centrum för molekylär medicin (UCMM),Umeå Univ, Umeå Ctr Mol Med, Johan Bures Vag 12, S-90187 Umeå, Sweden.(Swepub:umu)ulah0001
(author)
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Umeå universitetUmeå centrum för molekylär medicin (UCMM)
(creator_code:org_t)
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In:Scientific Reports: NATURE RESEARCH102045-2322
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Hahn, Max
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Nord, Christoffe ...
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Franklin, Oskar, ...
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Alanentalo, Toma ...
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Eriksson, Maria
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Morini, Federico
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Korsgren, Olle
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