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Activation of endog...
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Jönsson, Marie ELund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Molecular Neurogenetics,Lund University Research Groups,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine
(author)
Activation of endogenous retroviruses during brain development causes an inflammatory response
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-03
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EMBO Press,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-435948
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-435948URI
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https://doi.org/10.15252/embj.2020106423DOI
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https://lup.lub.lu.se/record/01956095-bde8-48fb-8ad2-a7955c2d8692URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146068675URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Endogenous retroviruses (ERVs) make up a large fraction of mammalian genomes and are thought to contribute to human disease, including brain disorders. In the brain, aberrant activation of ERVs is a potential trigger for an inflammatory response, but mechanistic insight into this phenomenon remains lacking. Using CRISPR/Cas9-based gene disruption of the epigenetic co-repressor protein Trim28, we found a dynamic H3K9me3-dependent regulation of ERVs in proliferating neural progenitor cells (NPCs), but not in adult neurons. In vivo deletion of Trim28 in cortical NPCs during mouse brain development resulted in viable offspring expressing high levels of ERVs in excitatory neurons in the adult brain. Neuronal ERV expression was linked to activated microglia and the presence of ERV-derived proteins in aggregate-like structures. This study demonstrates that brain development is a critical period for the silencing of ERVs and provides causal in vivo evidence demonstrating that transcriptional activation of ERV in neurons results in an inflammatory response.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Garza, RaquelLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Stamcellscentrum (SCC),Avdelningen för stamcellsforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Molecular Neurogenetics,Lund University Research Groups,Stem Cell Center,Division of stem cell research,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)ra7555ga
(author)
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Sharma, YogitaLund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Developmental and Regenerative Neurobiology,Lund University Research Groups,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine(Swepub:lu)yo4230sh
(author)
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Petri, RebeccaLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Molecular Neurogenetics,Lund University Research Groups,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine(Swepub:lu)med-rbp
(author)
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Södersten, ErikKarolinska Institute
(author)
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Johansson, Jenny GLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups(Swepub:lu)oft-jni
(author)
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Johansson, Pia ALund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups(Swepub:lu)pi2506jo
(author)
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Atacho, Diahann AmLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups(Swepub:lu)di4648at
(author)
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Pircs, KarolinaLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups(Swepub:lu)med-kpc
(author)
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Madsen, SofiaLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups(Swepub:lu)so6310ma
(author)
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Yudovich, DavidLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine(Swepub:lu)med-day
(author)
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Ramakrishnan, RamprasadLund University,Lunds universitet,Avdelningen för klinisk genetik,Institutionen för laboratoriemedicin,Medicinska fakulteten,Målinriktade behandlingar för leukemi,Forskargrupper vid Lunds universitet,Division of Clinical Genetics,Department of Laboratory Medicine,Faculty of Medicine,Targeted therapies in leukemia,Lund University Research Groups(Swepub:lu)med-rdr
(author)
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Holmberg, JohanKarolinska Institutet,Karolinska Institute
(author)
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Larsson, JonasLund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,WCMM- Wallenberg center för molekylär medicinsk forskning,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,WCMM-Wallenberg Centre for Molecular Medicine(Swepub:lu)molm-jla
(author)
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Jern, PatricUppsala University,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab(Swepub:uu)patrjern
(author)
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Jakobsson, JohanLund University,Lunds universitet,Molekylär neurogenetik,Forskargrupper vid Lunds universitet,Molecular Neurogenetics,Lund University Research Groups(Swepub:lu)mphy-jja
(author)
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Molekylär neurogenetikForskargrupper vid Lunds universitet
(creator_code:org_t)
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In:EMBO Journal: EMBO Press40:90261-41891460-2075
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- By the author/editor
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Jönsson, Marie E
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Garza, Raquel
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Sharma, Yogita
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Petri, Rebecca
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Södersten, Erik
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Johansson, Jenny ...
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show more...
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Johansson, Pia A
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Atacho, Diahann ...
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Pircs, Karolina
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Madsen, Sofia
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Yudovich, David
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Ramakrishnan, Ra ...
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Holmberg, Johan
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Larsson, Jonas
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Jern, Patric
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Jakobsson, Johan
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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NATURAL SCIENCES
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and Genetics
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EMBO Journal
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Uppsala University
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Lund University
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Karolinska Institutet