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  • Sharma, Hari ShankerUppsala universitet,Anestesiologi och intensivvård (author)

Pathophysiology of blood-brain barrier in brain tumor. : Novel therapeutic advances using nanomedicine

  • Article/chapterEnglish2020

Publisher, publication year, extent ...

  • LONDON ENGLAND :Elsevier,2020
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-436132
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-436132URI
  • https://doi.org/10.1016/bs.irn.2020.03.001DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:kap swepub-publicationtype

Notes

  • Glioblastoma Multiforme (GBM) is one the most common intracranial tumors discovered by Burns (1800) and Abernethy (1804) based on gross morphology of the autopsied material and referred to as "medullary sarcoma" and later "fungus medullare" (Abernethy, 1804; Burns, 1800). Virchow in 1863 was the first German pathologist using histomorphological techniques discovered that GBM is a tumor of glial origin. Virchow (1863/65) also then used the term Glioma for the first time and classified as low-grade glioma and high-grade glioma very similar to that of today according to World health organization (WHO) classification (Jellinger, 1978; Virchow, 1863/65). After almost >50 years of this discovery, Baily and Cushing (1926) based on modern neuropathological tools provide the classification of gliomas that is still valid today (Baily & Cushing, 1926). Although, our knowledge about development of gliomas has advanced through development of modern cellular and molecular biological tools (Gately, McLachlan, Dowling, & Philip, 2017; Omuro & DeAngelis, 2013), therapeutic advancement of GBM still requires lot of efforts for the benefit of patients. This review summarizes new developments on pathophysiological aspects of GBM and novel therapeutic strategies to enhance quality of life of patients. These novel therapeutic approaches rely on enhanced penetration of drug therapy into the tumor tissues by use of nanomedicine for both the diagnostic and therapeutic purposes, referred to as "theranostic nanomedicine" (Alphandery, 2020; Zhao, van Straten, Broekman, Preat, & Schiffelers, 2020). Although, the blood-brain barrier (BBB) is fenestrated around the periphery of the tumor tissues, the BBB is still tight within the deeper tissues of the tumor. Thus, drug delivery is a challenge for gliomas and requires new therapeutic advances (Zhao et al., 2020). Associated edema development around tumor tissues is another factor hindering therapeutic effects (Liu, Mei, & Lin, 2013). These factors are discussed in details using novel therapeutic advances in gliomas.

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  • Muresanu, Dafin F.Univ Med & Pharm, Dept Clin Neurosci, Cluj Napoca, Romania.;RoNeuro Inst Neurol Res & Diagnost, Cluj Napoca, Romania. (author)
  • Castellani, Rudy J.Univ Maryland, Dept Pathol, Baltimore, MD 21201 USA. (author)
  • Nozari, AlaMassachusetts Gen Hosp, Anesthesiol & Intens Care, Boston, MA 02114 USA. (author)
  • Vicente Lafuente, JoseUniv Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Bizkaia, Spain. (author)
  • Tian, Z. RyanUniv Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA. (author)
  • Sahib, SeaabUniv Arkansas, Dept Chem & Biochem, Fayetteville, AR 72701 USA. (author)
  • Bryukhovetskiy, IgorFar Eastern Fed Univ, Sch Biomed, Dept Fundamental Med, Vladivostok, Russia.;Russian Acad Sci, Far East Branch, Natl Sci Ctr Marine Biol, Pharmacol Lab, Vladivostok, Russia. (author)
  • Bryukhovetskiy, AndreyNeuroVita Clin Intervent & Restorat Neurol & Ther, Moscow, Russia. (author)
  • Buzoianu, Anca D.Iuliu Hatieganu Univ Med & Pharm, Dept Clin Pharmacol & Toxicol, Cluj Napoca, Romania. (author)
  • Patnaik, RanjanaBanaras Hindu Univ, Indian Inst Technol, Sch Biomed Engn, Dept Biomat, Varanasi, Uttar Pradesh, India. (author)
  • Wiklund, LarsUppsala universitet,Anestesiologi och intensivvård(Swepub:uu)larswikl (author)
  • Sharma, ArunaUppsala universitet,Anestesiologi och intensivvård,& Intens Care Med, Int Expt Cent Univ Basque Country UPV EHU, Dept Neurosci, LaNCE, Leioa, Bizkaia, Spain.(Swepub:uu)arush975 (author)
  • Uppsala universitetAnestesiologi och intensivvård (creator_code:org_t)

Related titles

  • In:Novel Therapeutic Advances In GlioblastomaLONDON ENGLAND : Elsevier, s. 1-669780128211144

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