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3D chitinous scaffo...
3D chitinous scaffolds derived from cultivated marine demosponge Aplysina aerophoba for tissue engineering approaches based on human mesenchymal stromal cells.
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Mutsenko, Vitalii V (author)
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Bazhenov, Vasilii V (author)
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Rogulska, Olena (author)
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Tarusin, Dmitriy N (author)
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Schütz, Kathleen (author)
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Brüggemeier, Sophie (author)
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Gossla, Elke (author)
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Akkineni, Ashwini R (author)
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Meißner, Heike (author)
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Lode, Anja (author)
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Meschke, Stephan (author)
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Ehrlich, Andre (author)
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Petović, Slavica (author)
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Martinović, Rajko (author)
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Djurović, Mirko (author)
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Stelling, Allison L (author)
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Nikulin, Sergey (author)
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- Rodin, Sergey (author)
- Karolinska Institutet,Uppsala universitet,Thoraxkirurgi
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Tonevitsky, Alexander (author)
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Gelinsky, Michael (author)
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Petrenko, Alexander Y (author)
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Glasmacher, Birgit (author)
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Ehrlich, Hermann (author)
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(creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: International Journal of Biological Macromolecules. - : Elsevier BV. - 0141-8130 .- 1879-0003. ; 104:Pt B, s. 1966-1974
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Subject headings
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- The recently discovered chitin-based scaffolds derived from poriferans have the necessary prosperities for potential use in tissue engineering. Among the various demosponges of the Verongida order, Aplysina aerophoba is an attractive target for more in-depth investigations, as it is a renewable source of unique 3D microporous chitinous scaffolds. We found these chitinous scaffolds were cytocompatible and supported attachment, growth and proliferation of human mesenchymal stromal cells (hMSCs) in vitro. Cultivation of hMSCs on the scaffolds for 7days resulted in a two-fold increase in their metabolic activity, indicating increased cell numbers. Cells cultured onto chitin scaffolds in differentiation media were able to differentiate into the chondrogenic, adipogenic and osteogenic lineages, respectively. These results indicate A. aerophoba is a novel source of chitin scaffolds to futher hMSCs-based tissue engineering strategies.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences (hsv//eng)
Keyword
- Chitin scaffolds
- Mesenchymal stromal cells
- Sponges
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mutsenko, Vitali ...
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Bazhenov, Vasili ...
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Rogulska, Olena
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Tarusin, Dmitriy ...
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Schütz, Kathleen
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Brüggemeier, Sop ...
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show more...
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Gossla, Elke
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Akkineni, Ashwin ...
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Meißner, Heike
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Lode, Anja
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Meschke, Stephan
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Ehrlich, Andre
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Petović, Slavica
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Martinović, Rajk ...
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Djurović, Mirko
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Stelling, Alliso ...
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Nikulin, Sergey
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Rodin, Sergey
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Tonevitsky, Alex ...
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Gelinsky, Michae ...
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Petrenko, Alexan ...
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Glasmacher, Birg ...
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Ehrlich, Hermann
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
- Articles in the publication
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International Jo ...
- By the university
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Uppsala University
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Karolinska Institutet