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Endotoxin removal i...
Endotoxin removal in septic shock with the Alteco LPS adsorber was safe but showed no benefit compared to placebo in the double-blind randomized controlled trial-the asset study
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- Lipcsey, Miklós (author)
- Uppsala universitet,Anestesiologi och intensivvård,Hedenstiernalaboratoriet,Uppsala Univ, Sweden
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- Tenhunen, Jyrki (author)
- Uppsala universitet,Anestesiologi och intensivvård,Uppsala Univ, Sweden
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- Pischke, Soeren E. (author)
- Oslo Univ Hosp, Div Emergencies & Crit Care, Oslo, Norway.;Univ Oslo, Dept Immunol, Oslo, Norway.
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- Kuitunen, Anne (author)
- Univ Tampere, Dept Intens Care, Tampere, Finland.;Tampere Univ Hosp, Tampere, Finland.
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- Flaatten, Hans (author)
- UiB Bergen, Dept Clin Med, Haukeland Univ Hosp, Bergen, Norway.
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- de Geer, Lina (author)
- Linköpings universitet,Avdelningen för klinisk kemi och farmakologi,Medicinska fakulteten,Region Östergötland, ANOPIVA US
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- Sjölin, Jan (author)
- Uppsala universitet,Infektionsmedicin,Uppsala Univ, Sweden
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- Frithiof, Robert (author)
- Karolinska Institutet,Uppsala universitet,Anestesiologi och intensivvård,Uppsala Univ, Sweden
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- Chew, Michelle S, 1969- (author)
- Linköpings universitet,Avdelningen för läkemedelsforskning,Medicinska fakulteten,Region Östergötland, ANOPIVA US
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- Bendel, Stepani (author)
- Kuopio Univ Hosp, Dept Intens Care, Kuopio, Finland.
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- Kawati, Rafael (author)
- Uppsala universitet,Anestesiologi och intensivvård,Uppsala Univ, Sweden
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- Larsson, Anders (author)
- Uppsala universitet,Klinisk kemi,Uppsala Univ, Sweden
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- Mollnes, Tom Eirik (author)
- Univ Oslo, Dept Immunol, Oslo, Norway.;Nordland Hosp, Res Lab, Bodo, Norway.;Univ Tromso, KG Jebsen TREC, Tromso, Norway.;Norwegian Univ Sci & Technol, Ctr Mol Inflammat Res, Trondheim, Norway.
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- Tonnessen, Tor Inge (author)
- Oslo Univ Hosp, Div Emergencies & Crit Care, Oslo, Norway.;Univ Oslo, Inst Clin Med, Oslo, Norway.
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- Rubertsson, Sten (author)
- Uppsala universitet,Anestesiologi och intensivvård,Uppsala Univ, Sweden
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(creator_code:org_t)
- Ovid Technologies (Wolters Kluwer Health), 2020
- 2020
- English.
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In: Shock. - : Ovid Technologies (Wolters Kluwer Health). - 1073-2322 .- 1540-0514. ; 54:2, s. 224-231
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Purpose: Lipopolysaccharides (LPS) are presumed to contribute to the inflammatory response in sepsis. We investigated if extracorporeal Alteco LPS Adsorber for LPS removal in early gram-negative septic shock was feasible and safe. Also, effects on endotoxin level, inflammatory response, and organ function were assessed.Methods: A pilot, double-blinded, randomized, Phase IIa, feasibility clinical investigation was undertaken in six Scandinavian intensive care units aiming to allocate 32 septic shock patients with abdominal or urogenital focus on LPS Adsorber therapy or a Sham Adsorber, therapy without active LPS binding. The study treatment was initiated within 12 h of inclusion and given for 6 h daily on first 2 days. LPS was measured in all patients.Results: The investigation was terminated after 527 days with eight patients included in the LPS Adsorber group and seven in the Sham group. Twenty-one adverse effects, judged not to be related to the device, were reported in three patients in the LPS Adsorber group and two in the Sham group. Two patients in the Sham group and no patients in the LPS Adsorber group died within 28 days. Plasma LPS levels were low without groups differences during or after adsorber therapy. The changes in inflammatory markers and organ function were similar in the groups.Conclusions: In a small cohort of patients with presumed gram-negative septic shock, levels of circulating endotoxin were low and no adverse effects within 28 days after LPS adsorber-treatment were observed. No benefit compared with a sham device was seen when using a LPS adsorber in addition to standard care.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Anestesi och intensivvård (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Anesthesiology and Intensive Care (hsv//eng)
Keyword
- Endotoxins
- gram-negative bacteria
- hemoperfusion
- septic shock
Publication and Content Type
- ref (subject category)
- art (subject category)
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Shock
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- By the author/editor
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Lipcsey, Miklós
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Tenhunen, Jyrki
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Pischke, Soeren ...
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Kuitunen, Anne
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Flaatten, Hans
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de Geer, Lina
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show more...
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Sjölin, Jan
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Frithiof, Robert
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Chew, Michelle S ...
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Bendel, Stepani
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Kawati, Rafael
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Larsson, Anders
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Mollnes, Tom Eir ...
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Tonnessen, Tor I ...
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Rubertsson, Sten
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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MEDICAL AND HEAL ...
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Shock
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Uppsala University
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Linköping University
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Karolinska Institutet