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Derivation and util...
Derivation and utility of an A beta-PET pathology accumulation index to estimate A beta load
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- Leuzy, Antoine (author)
- Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmö, Sweden.
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- Lillja, Johan (author)
- Uppsala universitet,Analytisk kemi,Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmö, Sweden.;Hermes Med Solut, Stockholm, Sweden.
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- Buckley, Christopher J. (author)
- GE Healthcare Life Sci, Amersham, England.
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- Ossenkoppele, Rik (author)
- Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmö, Sweden.;Vrije Univ Amsterdam, Neurosci Campus Amsterdam, Med Ctr, Amsterdam, Netherlands.
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- Palmqvist, Sebastian (author)
- Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmö, Sweden.;Skane Univ Hosp, Dept Neurol, Lund, Sweden.
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- Battle, Mark (author)
- GE Healthcare Life Sci, Amersham, England.
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- Farrar, Gill (author)
- GE Healthcare Life Sci, Amersham, England.
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- Thal, Dietmar R. (author)
- Campus Gasthuisberg, Lab Neuropathol, Dept Imaging & Pathol, Leuven, Belgium.;Campus Gasthuisberg, Leuven Brain Inst, Leuven, Belgium.;UZ Leuven, Dept Pathol, Leuven, Belgium.
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- Janelidze, Shorena (author)
- Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmö, Sweden.
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- Stomrud, Erik (author)
- Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmö, Sweden.;Skane Univ Hosp, Memory Clin, Lund, Sweden.
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- Strandberg, Olof (author)
- Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmö, Sweden.
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- Smith, Ruben (author)
- Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmö, Sweden.;Skane Univ Hosp, Dept Neurol, Lund, Sweden.
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- Hansson, Oskar (author)
- Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmö, Sweden.;Skane Univ Hosp, Memory Clin, Lund, Sweden.
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Lund Univ, Dept Clin Sci, Clin Memory Res Unit, Malmö, Sweden Analytisk kemi (creator_code:org_t)
- LIPPINCOTT WILLIAMS & WILKINS, 2020
- 2020
- English.
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In: Neurology. - : LIPPINCOTT WILLIAMS & WILKINS. - 0028-3878 .- 1526-632X. ; 95:21, s. E2834-E2844
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Abstract
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- Objective To evaluate a novel beta-amyloid (A beta)-PET-based quantitative measure (A beta accumulation index [A beta index]), including the assessment of its ability to discriminate between participants based on A beta status using visual read, CSF A beta(42)/A beta(40), and post-mortem neuritic plaque burden as standards of truth. Methods One thousand one hundred twenty-one participants (with and without cognitive impairment) were scanned with A beta-PET: Swedish BioFINDER, n = 392, [F-18]flutemetamol; Alzheimer's Disease Neuroimaging Initiative (ADNI), n = 692, [F-18]florbetapir; and a phase 3 end-of-life study, n = 100, [F-18] flutemetamol. The relationships between A beta index and standardized uptake values ratios (SUVR) from A beta-PET were assessed. The diagnostic performances of A beta index and SUVR were compared with visual reads, CSF A beta(42)/A beta(40), and A beta histopathology used as reference standards. Results Strong associations were observed between A beta index and SUVR (R-2: BioFINDER 0.951, ADNI 0.943, end-of-life, 0.916). Both measures performed equally well in differentiating A beta-positive from A beta-negative participants, with areas under the curve (AUCs) of 0.979 to 0.991 to detect abnormal visual reads, AUCs of 0.961 to 0.966 to detect abnormal CSF A beta(42)/A beta(40), and AUCs of 0.820 to 0.823 to detect abnormal A beta histopathology. Both measures also showed a similar distribution across postmortem-based A beta phases (based on anti-A beta 4G8 antibodies). Compared to models using visual read alone, the addition of the A beta index resulted in a significant increase in AUC and a decrease in Akaike information criterion to detect abnormal A beta histopathology. Conclusion The proposed A beta index showed a tight association to SUVR and carries an advantage over the latter in that it does not require the definition of regions of interest or the use of MRI. A beta index may thus prove simpler to implement in clinical settings and may also facilitate the comparison of findings using different A beta-PET tracers. Classification of evidence This study provides Class III evidence that the A beta accumulation index accurately differentiates A beta-positive from A beta-negative participants compared to A beta-PET visual reads, CSF A beta(42)/A beta(40), and A beta histopathology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
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Neurology
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- By the author/editor
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Leuzy, Antoine
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Lillja, Johan
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Buckley, Christo ...
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Ossenkoppele, Ri ...
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Palmqvist, Sebas ...
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Battle, Mark
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show more...
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Farrar, Gill
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Thal, Dietmar R.
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Janelidze, Shore ...
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Stomrud, Erik
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Strandberg, Olof
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Smith, Ruben
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Hansson, Oskar
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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Neurology
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Uppsala University