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Cytoskeletal Organi...
Cytoskeletal Organization Correlates to Motility and Invasiveness of Malignant Mesothelioma Cells
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- Keller, Maureen (author)
- Uppsala universitet,Vaskulärbiologi
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- Reis, Katarina (author)
- Karolinska Inst, Dept Microbiol Tumor & Cell Biol, SE-17177 Stockholm, Sweden.
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- Hjerpe, Anders (author)
- Karolinska Inst, Div Pathol, Dept Lab Med, SE-14157 Stockholm, Sweden.
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- Dobra, Katalin (author)
- Karolinska Institutet
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- Aspenström, Pontus (author)
- Uppsala universitet,Vaskulärbiologi
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(creator_code:org_t)
- 2021-02-08
- 2021
- English.
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In: Cancers. - : MDPI. - 2072-6694. ; 13:4
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Abstract
Subject headings
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- Malignant mesothelioma (MM) is a rare but highly aggressive cancer that primarily originates from the pleura, peritoneum or pericardium. There is a well-established link between asbestos exposure and progression of MM. Direct invasion of the surrounding tissues is the main feature of MM, which is dependent on dysregulated communication between the mesothelium and the microenvironment. This communication is dependent on the dynamic organization of the cytoskeleton. We have analyzed the organization and function of key cytoskeletal components in MM cell lines of increasing malignancies measured as migratory and invasive properties, and we show that highly malignant and invasive MM cells have an organization of the actin filament and vimentin systems that is distinct from the less malignant MM cell lines. In addition, the Hippo tumor suppressor pathway was inactivated in the invasive MM cells, which was seen as increased YAP nuclear localization.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- malignant mesothelioma
- cytoskeleton
- actin dynamics
- vimentin
- YAP
Publication and Content Type
- ref (subject category)
- art (subject category)
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