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Terpenoid bio-trans...
Terpenoid bio-transformations and applications via cell/organ cultures : a systematic review
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- Hegazy, Mohamed-Elamir F. (author)
- Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Dept Pharmaceut Biol, Staudinger Weg 5, D-55128 Mainz, Germany; Natl Res Ctr, Dept Phytochem, Giza, Egypt
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- Elshamy, Abdelsamed I. (author)
- Natl Res Ctr, Dept Nat Cpds Chem, Giza, Egypt; Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima, Japan
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- Mohamed, Tarik A. (author)
- Natl Res Ctr, Dept Phytochem, Giza, Egypt
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- Hussien, Taha A. (author)
- Deraya Univ, Fac Pharm, Pharmacognosy Dept, Al Minya, Egypt
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- Helaly, Soleiman E. (author)
- Helmholtz Ctr Infect Res, Dept Microbial Drugs, Braunschweig, Germany; Aswan Univ, Fac Sci, Dept Chem, Aswan, Egypt
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- Abdel-Azim, Nahla S. (author)
- Natl Res Ctr, Dept Phytochem, Giza, Egypt
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- Shams, Khaled A. (author)
- Natl Res Ctr, Dept Phytochem, Giza, Egypt
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- Shahat, Abdelaaty A. (author)
- Natl Res Ctr, Dept Phytochem, Giza, Egypt; King Saud Univ, Coll Pharm, Pharmacognosy Dept, Riyadh, Saudi Arabia
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- Tawfik, Wafaa A. (author)
- Natl Res Ctr, Dept Phytochem, Giza, Egypt
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- Shahen, Alaa M. (author)
- Natl Res Ctr, Dept Phytochem, Giza, Egypt
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- Debbab, Abdessamad (author)
- Debbab Med, Munich, Germany
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- El-Seedi, Hesham R. (author)
- Uppsala universitet,Farmakognosi,Menoufia Univ, Fac Sci, Dept Chem, Shibin Al Kawm, Egypt; Jiangsu Univ, Coll Food & Biol Engn, Zhenjiang, Jiangsu, Peoples R China
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- Mohamed, Abou El-Hamd H. (author)
- Aswan Univ, Fac Sci, Dept Chem, Aswan, Egypt
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- Hammouda, Faiza M. (author)
- Natl Res Ctr, Dept Phytochem, Giza, Egypt
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- Sakr, Mahmoud (author)
- Natl Res Ctr, Genet Engn & Biotech Div, Giza, Egypt; Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA
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- Paré, Paul W. (author)
- Texas Tech Univ, Dept Chem & Biochem, Lubbock, TX 79409 USA
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- Efferth, Thomas (author)
- Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, Dept Pharmaceut Biol, Staudinger Weg 5, D-55128 Mainz, Germany
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(creator_code:org_t)
- 2019-10-30
- 2020
- English.
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In: Critical reviews in biotechnology. - : Informa UK Limited. - 0738-8551 .- 1549-7801. ; 40:1, s. 64-82
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Structurally diverse natural products are valued for their targeted biological activity. The challenge of working with such metabolites is their low natural abundance and complex structure, often with multiple stereocenters, precludes large-scale or unsophisticated chemical synthesis. Since select plants contain the enzymatic machinery necessary to produce specialized compounds, tissue cultures can be used to achieve key transformations for large-scale chemical and/or pharmaceutical applications. In this context, plant tissue-culture bio-transformations have demonstrated great promise in the preparation of pharmaceutical products. This review describes the capacity of cultured plant cells to transform terpenoid natural products and the specific application of such transformations over the past three decades (1988-2019).
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- Terpenoid
- natural metabolites
- enzymatic biotransformations
- plant cell cultures
- active natural product derivatives
- Pharmaceutical products
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Hegazy, Mohamed- ...
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Elshamy, Abdelsa ...
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Mohamed, Tarik A ...
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Hussien, Taha A.
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Helaly, Soleiman ...
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Abdel-Azim, Nahl ...
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Shams, Khaled A.
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Shahat, Abdelaat ...
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Tawfik, Wafaa A.
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Shahen, Alaa M.
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Debbab, Abdessam ...
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El-Seedi, Hesham ...
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Mohamed, Abou El ...
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Hammouda, Faiza ...
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Sakr, Mahmoud
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Paré, Paul W.
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Efferth, Thomas
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Uppsala University