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ILC1 drive intestin...
ILC1 drive intestinal epithelial and matrix remodelling
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- Jowett, Geraldine M. (author)
- Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England; Kings Coll London, Ctr Host Microbiome Interact, London, England; Wellcome Trust Cell Therapies & Regenerat Med PhD, London, England; Kings Coll London, Ctr Stem Cells & Regenerat Med, London, England
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- Norman, Michael D. A. (author)
- Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England
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- Yu, Tracy T. L. (author)
- Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England
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- Rosell Arevalo, Patricia (author)
- Kings Coll London, Ctr Host Microbiome Interact, London, England
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- Hoogland, Dominique (author)
- Kings Coll London, Dept Chem, London, England
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- Lust, Suzette T. (author)
- Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England
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- Read, Emily (author)
- Kings Coll London, Ctr Host Microbiome Interact, London, England; Wellcome Trust Cell Therapies & Regenerat Med PhD, London, England
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- Hamrud, Eva (author)
- Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England; Wellcome Trust Cell Therapies & Regenerat Med PhD, London, England; Kings Coll London, Ctr Stem Cells & Regenerat Med, London, England
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- Walters, Nick J. (author)
- Tampere Univ Tampere Finland, BioMediTech, Helsinki, Finland; Nat Resources Inst Finland, Helsinki, Finland
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- Niazi, Umar (author)
- Guys & St Thomas Natl Hlth Serv Fdn Trust, London, England.;Kings Coll London, Natl Inst Hlth Res Biomed Res, Ctr Translat Bioinformat Platform, Guys Hosp, London, England
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- Chung, Matthew Wai Heng (author)
- Kings Coll London, Ctr Host Microbiome Interact, London, England; Wellcome Trust Cell Therapies & Regenerat Med PhD, London, England; Kings Coll London, Ctr Stem Cells & Regenerat Med, London, England
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- Marciano, Daniele (author)
- Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England
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- Omer, Omer S. (author)
- Kings Coll London, Sch Immunol & Microbial Sci, London, England; Guys & St Thomas Hosp NHS Trust, Dept Gastroenterol, London, England
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- Zabinski, Tomasz (author)
- Kings Coll London, Ctr Host Microbiome Interact, London, England
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- Danovi, Davide (author)
- Kings Coll London, Ctr Stem Cells & Regenerat Med, London, England
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- Lord, Graham M. (author)
- Univ Manchester, Fac Biol Med & Hlth, Manchester, Lancs, England
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- Hilborn, Jöns, 1956- (author)
- Uppsala universitet,Polymerkemi
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- Evans, Nicholas D. (author)
- Univ Southampton, Ctr Human Dev Stem Cells & Regenerat Human Dev &, Inst Dev Sci, Bone & Joint Res Grp, Southampton, Hants, England
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- Dreiss, Cécile A. (author)
- Kings Coll London, Inst Pharmaceut Sci, London, England
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- Bozec, Laurent (author)
- Univ Toronto, Fac Dent, Toronto, ON, Canada
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- Oommen, Oommen P. (author)
- Tampere Univ, Fac Med & Hlth Technol, Bioengn & Nanomed Lab, Tampere, Finland
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- Lorenz, Christian D. (author)
- Kings Coll London, Dept Phys, London, England
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- da Silva, Ricardo M. P. (author)
- Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England; Univ Porto, i3S Inst Invest & Inovacao Saude, Porto, Portugal; Univ Porto, INEB Inst Engn Biomed, Porto, Portugal
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- Neves, Joana F. (author)
- Kings Coll London, Ctr Host Microbiome Interact, London, England
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- Gentleman, Eileen (author)
- Kings Coll London, Ctr Craniofacial & Regenerat Biol, London, England
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(creator_code:org_t)
- 2020-09-07
- 2021
- English.
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In: Nature Materials. - : Springer Nature. - 1476-1122 .- 1476-4660. ; 20:2, s. 250-259
- Related links:
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https://eprints.soto...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- Organoids can shed light on the dynamic interplay between complex tissues and rare cell types within a controlled microenvironment. Here, we develop gut organoid cocultures with type-1 innate lymphoid cells (ILC1) to dissect the impact of their accumulation in inflamed intestines. We demonstrate that murine and human ILC1 secrete transforming growth factor β1, driving expansion of CD44v6+ epithelial crypts. ILC1 additionally express MMP9 and drive gene signatures indicative of extracellular matrix remodelling. We therefore encapsulated human epithelial–mesenchymal intestinal organoids in MMP-sensitive, synthetic hydrogels designed to form efficient networks at low polymer concentrations. Harnessing this defined system, we demonstrate that ILC1 drive matrix softening and stiffening, which we suggest occurs through balanced matrix degradation and deposition. Our platform enabled us to elucidate previously undescribed interactions between ILC1 and their microenvironment, which suggest that they may exacerbate fibrosis and tumour growth when enriched in inflamed patient tissues.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Jowett, Geraldin ...
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Norman, Michael ...
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Yu, Tracy T. L.
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Rosell Arevalo, ...
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Hoogland, Domini ...
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Lust, Suzette T.
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show more...
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Read, Emily
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Hamrud, Eva
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Walters, Nick J.
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Niazi, Umar
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Chung, Matthew W ...
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Marciano, Daniel ...
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Omer, Omer S.
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Zabinski, Tomasz
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Danovi, Davide
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Lord, Graham M.
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Hilborn, Jöns, 1 ...
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Evans, Nicholas ...
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Dreiss, Cécile A ...
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Bozec, Laurent
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Oommen, Oommen P ...
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Lorenz, Christia ...
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da Silva, Ricard ...
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Neves, Joana F.
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Gentleman, Eilee ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Immunology
- Articles in the publication
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Nature Materials
- By the university
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Uppsala University