Sökning: onr:"swepub:oai:DiVA.org:uu-439657" >
Inhibition of hippo...
Inhibition of hippocampal OLMα2 cells rescue nicotine induced memory impairment
-
- Siwani, Samer (författare)
- Uppsala universitet,Kullander: Funktionella neuronala nätverk
-
- S. C. França, Arthur (författare)
- Brain institute, Federal University of Rio Grande do Norte, Natal - Brazil,Computational Neurophysiology
-
- Adžemović, Ahmed (författare)
- Uppsala universitet,Kullander: Funktionella neuronala nätverk
-
visa fler...
-
- Tort, Adriano B.L. (författare)
- Brain institute, Federal University of Rio Grande do Norte, Natal - Brazil,Computational Neurophysiology
-
- Kullander, Klas, 1966- (författare)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk cellbiologi,Kullander: Funktionella neuronala nätverk
-
visa färre...
-
(creator_code:org_t)
- Engelska.
- Relaterad länk:
-
https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Nicotine is a commonly used drug that has been extensively studied for decades. Some of these studies have found cognitive enhancing effects; however, they were usually based on moderate and not the higher doses to which the regular consumer might be accustomed. Here we investigate how higher doses of nicotine may influence the performance of mice in object recognition and in the Y-maze. Further, we examined specific circuits underlying the hippocampal-dependent effects by targeting a subgroup of inhibitory interneurons, referred to as OLMα2 cells. We subjected mice to nicotine during an object recognition task and a working memory task. We found that a high dose of 1.5 mg/kg nicotine impaired memory performance in the object recognition task but not in the working memory task. It was previously demonstrated that OLMα2 cells bidirectionally affect learning in the object recognition task and that these cells respond to nicotine. Subsequently, we subjected mice to nicotine while optogenetically inhibiting OLMα2 cells and found that this intervention reversed the nicotine-induced memory impairment. We conclude that some learning and memory effects from nicotine are hippocampus dependent and are probably mediated by OLMα2 cells.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Neuroscience
- Neurovetenskap
Publikations- och innehållstyp
- vet (ämneskategori)
- ovr (ämneskategori)