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- Zhang, JuqingNorthwest A&F Univ, Coll Vet Med, Shaanxi Ctr Stem Cells Engn & Technol, Yangling 712100, Shaanxi, Peoples R China. (author)
Super enhancers-Functional cores under the 3D genome
- Article/chapterEnglish2021
Publisher, publication year, extent ...
- 2020-12-17
- John Wiley & Sons,2021
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-439674
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-439674URI
- https://doi.org/10.1111/cpr.12970DOI
Supplementary language notes
- Language:English
- Summary in:English
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- SwePubSwePub
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Notes
- Complex biochemical reactions take place in the nucleus all the time. Transcription machines must follow the rules. The chromatin state, especially the three-dimensional structure of the genome, plays an important role in gene regulation and expression. The super enhancers are important for defining cell identity in mammalian developmental processes and human diseases. It has been shown that the major components of transcriptional activation complexes are recruited by super enhancer to form phase-separated condensates. We summarize the current knowledge about super enhancer in the 3D genome. Furthermore, a new related transcriptional regulation model from super enhancer is outlined to explain its role in the mammalian cell progress.
Subject headings and genre
- NATURVETENSKAP Biologi Cellbiologi hsv//swe
- NATURAL SCIENCES Biological Sciences Cell Biology hsv//eng
- 3D genome
- biological processes
- phase‐
- separated condensates
- super enhancer
- transcription model
Added entries (persons, corporate bodies, meetings, titles ...)
- Yue, WeiNorthwest A&F Univ, Coll Vet Med, Shaanxi Ctr Stem Cells Engn & Technol, Yangling 712100, Shaanxi, Peoples R China. (author)
- Zhou, YaqiNorthwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China. (author)
- Liao, MingzhiNorthwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China. (author)
- Chen, XingqiUppsala universitet,Molekylära verktyg(Swepub:uu)xinch196 (author)
- Hua, JinlianNorthwest A&F Univ, Coll Vet Med, Shaanxi Ctr Stem Cells Engn & Technol, Yangling 712100, Shaanxi, Peoples R China. (author)
- Northwest A&F Univ, Coll Vet Med, Shaanxi Ctr Stem Cells Engn & Technol, Yangling 712100, Shaanxi, Peoples R China.Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China. (creator_code:org_t)
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- In:Cell Proliferation: John Wiley & Sons54:20960-77221365-2184
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