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Patterns of Human L...
Patterns of Human Leukocyte Antigen Class I and Class II Associations and Cancer
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- Liu, Zhiwei (author)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA
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- Derkach, Andriy (author)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA; Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA
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- Yu, Kelly J. (author)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA
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- Yeager, Meredith (author)
- NCI, Div Canc Epidemiol & Genet, Canc Genom Res Lab, Bethesda, MD 20892 USA; Frederick Natl Lab Canc Res, Frederick, MD USA
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- Chang, Yu-Sun (author)
- Chang Gung Univ, Dept Microbiol & Immunol, Taoyuan, Taiwan; Chang Gung Univ, Mol Med Res Ctr, Taoyuan, Taiwan.;Chang Gung Mem Hosp, Dept Otolaryngol Head & Neck Surg, Linkou, Taiwan
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- Chen, Chien-Jen (author)
- Acad Sinica, Gen Res Ctr, Taipei, Taiwan
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- Gyllensten, Ulf (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Medicinsk genetik och genomik
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- Lan, Qing (author)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA
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- Lee, Mei-Hsuan (author)
- Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan
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- McKay, James D. (author)
- WHO, Int Agcy Res Canc, Lyon, France
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- Rothman, Nathaniel (author)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA
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- Yang, Hwai-I (author)
- Acad Sinica, Gen Res Ctr, Taipei, Taiwan; Natl Yang Ming Univ, Inst Clin Med, Taipei, Taiwan; Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung, Taiwan
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- Hildesheim, Allan (author)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA
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- Pfeiffer, Ruth M. (author)
- NCI, Div Canc Epidemiol & Genet, Rockville, MD 20850 USA
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(creator_code:org_t)
- American Association For Cancer Research (AACR), 2021
- 2021
- English.
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In: Cancer Research. - : American Association For Cancer Research (AACR). - 0008-5472 .- 1538-7445. ; 81:4, s. 1148-1152
- Related links:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Human leukocyte antigen (HLA) gene variation is associated with risk of cancers, particularly those with infectious etiology or hematopoietic origin, given its role in immune presentation. Previous studies focused primarily on HLA allele/haplotype-specific associations. To answer whether associations are driven by HLA class I (essential for T-cell cytotoxicity) or class II (important for T-cell helper responses) genes, we analyzed GWAS from 24 case–control studies and consortia comprising 27 cancers (totaling >71,000 individuals). Associations for most cancers with infectious etiology or of hematopoietic origin were driven by multiple HLA regions, suggesting that both cytotoxic and helper T-cell responses are important. Notable exceptions were observed for nasopharyngeal carcinoma, an EBV-associated cancer, and CLL/SLL forms of non-Hodgkin lymphomas; these cancers were associated with HLA class I region only and HLA class II region only, implying the importance of cytotoxic T-cell responses for the former and CD4+ T-cell helper responses for the latter. Our findings suggest that increased understanding of the pattern of HLA associations for individual cancers could lead to better insights into specific mechanisms involved in cancer pathogenesis.Significance: GWAS of >71,000 individuals across 27 cancer types suggest that patterns of HLA Class I and Class II associations may provide etiologic insights for cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
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- ref (subject category)
- art (subject category)
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- By the author/editor
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Liu, Zhiwei
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Derkach, Andriy
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Yu, Kelly J.
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Yeager, Meredith
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Chang, Yu-Sun
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Chen, Chien-Jen
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show more...
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Gyllensten, Ulf
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Lan, Qing
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Lee, Mei-Hsuan
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McKay, James D.
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Rothman, Nathani ...
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Yang, Hwai-I
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Hildesheim, Alla ...
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Pfeiffer, Ruth M ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Cancer Research
- By the university
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Uppsala University