Search: onr:"swepub:oai:DiVA.org:uu-440712" >
Increased periphera...
Increased peripheral levels of TARC/CCL17 in first episode psychosis patients
-
- Malmqvist, Anna (author)
- Karolinska Institutet
-
- Schwieler, Lilly (author)
- Karolinska Institutet
-
- Orhan, Funda (author)
- Karolinska Institutet
-
show more...
-
- Fatouros-Bergman, Helena (author)
- Karolinska Institutet
-
- Bauer, Markus (author)
- Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden.
-
- Flyckt, Lena (author)
- Karolinska Institutet
-
- Cervenka, Simon (author)
- Karolinska Institutet
-
- Engberg, Goran (author)
- Karolinska Institutet
-
- Piehl, Fredrik (author)
- Karolinska Institutet
-
- Erhardt, Sophie (author)
- Karolinska Institutet
-
- Farde, L. (author)
- Karolinska Institutet
-
- Flyckt, L. (author)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
-
- Engberg, G. (author)
- Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden.
-
- Erhardt, S. (author)
- Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden.
-
- Fatouros-Bergman, H. (author)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
-
- Cervenka, S. (author)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
-
- Schwieler, L. (author)
- Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden.
-
- Piehl, F. (author)
- Karolinska Inst, Dept Clin Neurosci, Neuroimmunol Unit, Stockholm, Sweden.
-
- Agartz, I (author)
- Karolinska Institutet
-
- Collste, K. (author)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
-
- Victorsson, P. (author)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm, Sweden.
-
- Malmqvist, A. (author)
- Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden.
-
- Hedberg, M. (author)
- Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden.
-
- Orhan, F. (author)
- Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden.
-
show less...
-
Karolinska Institutet Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden (creator_code:org_t)
- ELSEVIER, 2019
- 2019
- English.
-
In: Schizophrenia Research. - : ELSEVIER. - 0920-9964 .- 1573-2509. ; 210, s. 221-227
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Background: Evidence for a link between the pathophysiology of schizophrenia and the immune system is mounting. Altered levels of chemokines in plasma have previously been reported in patients with schizophrenia under antipsychotic medication. Here we aimed to study both peripheral and central chemokine levels in drugnaive or short-time medicated first episode psychosis (FEP) patients. Method: We analyzed nine chemokines in plasma and CSF from 41 FEP patients and 22 healthy controls using electrochemiluminescence assay. Results: In plasma four chemokines; TARC/CCL17, eotaxin/CCL11, MDC/CCL22, IP-10/CXCL10 and in CSF one chemokine; IP-10/CXCL10 showed reliable detection in N50% of the cases. FEP patients displayed increased levels of TARC/CCL17 in plasma compared to healthy controls, 89.6 (IQR 66.2-125.8) pg/mL compared to 48.6 (IQR 28.0-71.7) pg/mL (p = 0.001). The difference was not attributed to confounding factors. Plasma TARC/CCL17 was not associated with PANSS, CGI or GAF scores, neither with cognitive functions. The chemokines eotaxin/CCL11, MDC/CCL22, IP-10/CXCL10 in plasma and IP-10/CXCL10 in CSF did not differ between FEP patients and controls. Conclusion: In line with a previous study showing that chronic patients with schizophrenia display increased plasma TARC/CCL17 levels, we here found an elevation in FEP patients suggesting a role of TARC/CCL17 in early stages of schizophrenia. The exactmechanism of this involvement is still unknown and future longitudinal studies as well as studies of central and peripheral chemokine levels would be of great interest. (C) 2018 Elsevier B.V. All rights reserved.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Schizophrenia
- Chemokines
- Eotaxin/CCL11
- MDC/CCL22
- IP-10/CXCL10
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Malmqvist, Anna
-
Schwieler, Lilly
-
Orhan, Funda
-
Fatouros-Bergman ...
-
Bauer, Markus
-
Flyckt, Lena
-
show more...
-
Cervenka, Simon
-
Engberg, Goran
-
Piehl, Fredrik
-
Erhardt, Sophie
-
Farde, L.
-
Flyckt, L.
-
Engberg, G.
-
Erhardt, S.
-
Fatouros-Bergman ...
-
Cervenka, S.
-
Schwieler, L.
-
Piehl, F.
-
Agartz, I
-
Collste, K.
-
Victorsson, P.
-
Malmqvist, A.
-
Hedberg, M.
-
Orhan, F.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
- Articles in the publication
-
Schizophrenia Re ...
- By the university
-
Uppsala University
-
Karolinska Institutet