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Extrastriatal dopam...
Extrastriatal dopamine D2-receptor availability in social anxiety disorder
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- Plaven-Sigray, Pontus (author)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden.
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- Hedman, Erik (author)
- Karolinska Institutet
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- Victorsson, Pauliina (author)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden.;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden.
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- Matheson, Granville J. (author)
- Karolinska Institutet
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- Forsberg, Anton (author)
- Karolinska Institutet
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- Djurfeldt, Diana R. (author)
- Karolinska Institutet
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- Ruck, Christian (author)
- Karolinska Institutet
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- Halldin, Christer (author)
- Karolinska Institutet
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- Lindefors, Nils (author)
- Karolinska Institutet
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- Cervenka, Simon (author)
- Karolinska Institutet
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Karolinska Institutet Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, Stockholm, Sweden;Stockholm Cty Council, Stockholm Hlth Care Serv, Stockholm, Sweden. (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
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In: European Neuropsychopharmacology. - : Elsevier BV. - 0924-977X .- 1873-7862. ; 27:5, s. 462-469
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Abstract
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- Alterations in the dopamine system are hypothesized to influence the expression of social anxiety disorder (SAD) symptoms. However, molecular imaging studies comparing dopamine function between patients and control subjects have yielded conflicting results. Importantly, while all previous investigations focused on the striatum, findings from activation and blood flow studies indicate that prefrontal and limbic brain regions have a central role in the pathophysiology. The objective of this study was to investigate extrastriatal dopamine D2-receptor (D2-R) availability in SAD. We examined 12 SAD patients and 16 healthy controls using positron emission tomography and the high-affinity D2-R radioligand [C-11]FLB457. Parametric images of D2-R binding potential were derived using the Logan graphical method with cerebellum as reference region. Two-tailed one-way independent ANCOVAs, with age as covariate, were used to examine differences in D2-R availability between groups using both region-based and voxel-wise analyses. The region-based analysis showed a medium effect size of higher D2-R levels in the orbitofrontal cortex (OFC) in patients, although this result did not remain significant after correction for multiple comparisons. The voxel-wise comparison revealed elevated D2-R availability in patients within OFC and right dorsolateral prefrontal cortex after correction for multiple comparisons. These preliminary results suggest that an aberrant extrastriatal dopamine system may be part of the disease mechanism in SAD.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Phobic disorders
- Positron-Emission tomography
- Dopamine
- Receptors
- Dopamine D2
- Prefrontal cortex
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Plaven-Sigray, P ...
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Hedman, Erik
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Victorsson, Paul ...
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Matheson, Granvi ...
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Forsberg, Anton
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Djurfeldt, Diana ...
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Ruck, Christian
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Halldin, Christe ...
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Lindefors, Nils
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Cervenka, Simon
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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European Neurops ...
- By the university
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Uppsala University
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Karolinska Institutet