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- Cervenka, SimonKarolinska Institutet (author)
PET radioligands for the dopamine D1-receptor : Application in psychiatric disorders
- Article/chapterEnglish2019
Publisher, publication year, extent ...
- Elsevier BV,2019
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-440763
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440763URI
- https://doi.org/10.1016/j.neulet.2018.03.007DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:140204557URI
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- Language:English
- Summary in:English
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Notes
- The dopamine (DA) system is considered to be centrally involved in the pathophysiotogy of several major psychiatric disorders. Using positron emission tomography (PET), aberrations in dopamine D2/D3-receptors (D2-R) levels and uptake of the DA precursor FDOPA have been shown for schizophrenia, substance abuse and depression. Radioligands for the dopamine D1-receptor (D1-R) have been available for more than three decades, however this receptor subtype has received much less attention in psychiatry research. Here, studies investigating D1-R in psychiatric patients in comparison to healthy control subjects are summarized. Although small sample sizes, medication effects and heterogeneous methods of quantification limit the conclusions that can be drawn, the data is suggestive of higher levels of cortical D1-R in drug naive patients with psychosis, and lower D1-R in patients with affective disorders. Data sharing and reanalysis using harmonized methodology are important next steps towards clarifying the role of D1-R in these disorders.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Psykiatri hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Psychiatry hsv//eng
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- PET
- Dopamine
- D1
- Schizophrenia
- Depression
- Substance use disorder
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- Karolinska Institutet (creator_code:org_t)
Related titles
- In:Neuroscience Letters: Elsevier BV691, s. 26-340304-39401872-7972
Internet link
- https://doi.org/10.1016/j.neulet.2018.03.007Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1545940/FULLTEXT01.pdffulltext:print
- https://doi.org/10.1016/j.neulet.2018.03.007
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440763
- https://doi.org/10.1016/j.neulet.2018.03.007
- http://kipublications.ki.se/Default.aspx?queryparsed=id:140204557
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