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Assessing brain imm...
Assessing brain immune activation in psychiatric disorders : clinical and preclinical PET imaging studies of the 18-kDa translocator protein
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- van der Doef, Thalia F. (author)
- Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands.
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- Doorduin, Janine (author)
- Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands.
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- van Berckel, Bart N. M. (author)
- Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands.;Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands.
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- Cervenka, Simon (author)
- Karolinska Institutet
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Univ Med Ctr Utrecht, Dept Psychiat, Utrecht, Netherlands;Vrije Univ Amsterdam, Med Ctr, Dept Radiol & Nucl Med, Amsterdam, Netherlands. Univ Groningen, Univ Med Ctr Groningen, Dept Nucl Med & Mol Imaging, Groningen, Netherlands. (creator_code:org_t)
- 2015-09-10
- 2015
- English.
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In: CLINICAL AND TRANSLATIONAL IMAGING. - : Springer Nature. - 2281-5872 .- 2281-7565. ; 3:6, s. 449-460
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Abstract
Subject headings
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- Accumulating evidence from different lines of research suggests an involvement of the immune system in the pathophysiology of several psychiatric disorders. During recent years, a series of positron emission tomography (PET) studies have been published using radioligands for the translocator protein (TSPO) to study microglia activation in schizophrenia, bipolar I disorder, major depression, autism spectrum disorder, and drug abuse. The results have been somewhat conflicting, which could be due to differences both in patient sample characteristics and in PET methods. In particular, further work is needed to address both methodological and biological sources of variability in TSPO levels, a process in which the use of animal models and small animal PET systems can be a valuable tool. Given this development, PET studies of immune activation have the potential to further increase our understanding of disease mechanisms in psychiatric disorders, which is a requisite in the search for new treatment approaches. Furthermore, molecular imaging could become an important clinical tool for identifying specific subgroups of patients or disease stages that would benefit from treatment targeting the immune system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Psychiatry
- PET
- Neuroinflammation
- Microglia
- TSPO
Publication and Content Type
- ref (subject category)
- for (subject category)
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