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Brain Age Predictio...
Brain Age Prediction Reveals Aberrant Brain White Matter in Schizophrenia and Bipolar Disorder : A Multisample Diffusion Tensor Imaging Study
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Tønnesen, Siren (author)
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Kaufmann, Tobias (author)
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de Lange, Ann-Marie G (author)
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Richard, Geneviève (author)
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Doan, Nhat Trung (author)
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Alnæs, Dag (author)
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van der Meer, Dennis (author)
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Rokicki, Jaroslav (author)
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Moberget, Torgeir (author)
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Maximov, Ivan I (author)
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- Agartz, Ingrid (author)
- Karolinska Institutet
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Aminoff, Sofie R (author)
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Beck, Dani (author)
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Barch, Deanna M (author)
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Beresniewicz, Justyna (author)
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- Cervenka, Simon (author)
- Karolinska Institutet
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- Fatouros-Bergman, Helena (author)
- Karolinska Institutet
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Craven, Alexander R (author)
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- Flyckt, Lena (author)
- Karolinska Institutet
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Gurholt, Tiril P (author)
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Haukvik, Unn K (author)
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Hugdahl, Kenneth (author)
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Johnsen, Erik (author)
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- Jönsson, Erik G (author)
- Karolinska Institutet
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Kolskår, Knut K (author)
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Kroken, Rune Andreas (author)
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Lagerberg, Trine V (author)
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Løberg, Else-Marie (author)
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Nordvik, Jan Egil (author)
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Sanders, Anne-Marthe (author)
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Ulrichsen, Kristine (author)
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Andreassen, Ole A (author)
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Westlye, Lars T (author)
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- English.
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In: Biological Psychiatry. - : Elsevier BV. - 2451-9022 .- 2451-9030. ; 5:12, s. 1095-1103
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
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- BACKGROUND: Schizophrenia (SZ) and bipolar disorder (BD) share substantial neurodevelopmental components affecting brain maturation and architecture. This necessitates a dynamic lifespan perspective in which brain aberrations are inferred from deviations from expected lifespan trajectories. We applied machine learning to diffusion tensor imaging (DTI) indices of white matter structure and organization to estimate and compare brain age between patients with SZ, patients with BD, and healthy control (HC) subjects across 10 cohorts.METHODS: We trained 6 cross-validated models using different combinations of DTI data from 927 HC subjects (18-94 years of age) and applied the models to the test sets including 648 patients with SZ (18-66 years of age), 185 patients with BD (18-64 years of age), and 990 HC subjects (17-68 years of age), estimating the brain age for each participant. Group differences were assessed using linear models, accounting for age, sex, and scanner. A meta-analytic framework was applied to assess the heterogeneity and generalizability of the results.RESULTS: Tenfold cross-validation revealed high accuracy for all models. Compared with HC subjects, the model including all feature sets significantly overestimated the age of patients with SZ (Cohen's d = -0.29) and patients with BD (Cohen's d = 0.18), with similar effects for the other models. The meta-analysis converged on the same findings. Fractional anisotropy-based models showed larger group differences than the models based on other DTI-derived metrics.CONCLUSIONS: Brain age prediction based on DTI provides informative and robust proxies for brain white matter integrity. Our results further suggest that white matter aberrations in SZ and BD primarily consist of anatomically distributed deviations from expected lifespan trajectories that generalize across cohorts and scanners.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Bipolar
- Brain age
- DTI
- Machine learning
- Psychosis
- Schizophrenia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Tønnesen, Siren
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Kaufmann, Tobias
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de Lange, Ann-Ma ...
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Richard, Geneviè ...
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Doan, Nhat Trung
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Alnæs, Dag
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show more...
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van der Meer, De ...
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Rokicki, Jarosla ...
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Moberget, Torgei ...
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Maximov, Ivan I
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Agartz, Ingrid
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Aminoff, Sofie R
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Beck, Dani
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Barch, Deanna M
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Beresniewicz, Ju ...
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Cervenka, Simon
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Fatouros-Bergman ...
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Craven, Alexande ...
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Flyckt, Lena
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Gurholt, Tiril P
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Haukvik, Unn K
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Hugdahl, Kenneth
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Johnsen, Erik
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Jönsson, Erik G
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Kolskår, Knut K
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Kroken, Rune And ...
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Lagerberg, Trine ...
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Løberg, Else-Mar ...
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Nordvik, Jan Egi ...
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Sanders, Anne-Ma ...
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Ulrichsen, Krist ...
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Andreassen, Ole ...
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Westlye, Lars T
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Biological Psych ...
- By the university
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Uppsala University
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Karolinska Institutet