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- Orhan, FKarolinska Institutet (author)
CSF GABA is reduced in first-episode psychosis and associates to symptom severity
- Article/chapterEnglish2018
Publisher, publication year, extent ...
- 2017-03-14
- Springer Nature,2018
- electronicrdacarrier
Numbers
- LIBRIS-ID:oai:DiVA.org:uu-440807
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440807URI
- https://doi.org/10.1038/mp.2017.25DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:138214059URI
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- Language:English
- Summary in:English
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- Schizophrenia is characterized by a multiplicity of symptoms arising from almost all domains of mental function. γ-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain and is increasingly recognized to have a significant role in the pathophysiology of the disorder. In the present study, cerebrospinal fluid (CSF) concentrations of GABA were analyzed in 41 first-episode psychosis (FEP) patients and 21 age- and sex-matched healthy volunteers by high-performance liquid chromatography. We found lower CSF GABA concentration in FEP patients compared with that in the healthy volunteers, a condition that was unrelated to antipsychotic and/or anxiolytic medication. Moreover, lower CSF GABA levels were associated with total and general score of Positive and Negative Syndrome Scale, illness severity and probably with a poor performance in a test of attention. This study offers clinical in vivo evidence for a potential role of GABA in early-stage schizophrenia.
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- Fatouros-Bergman, HKarolinska Institutet (author)
- Goiny, MKarolinska Institutet (author)
- Malmqvist, AKarolinska Institutet (author)
- Piehl, FKarolinska Institutet (author)
- Cervenka, SimonKarolinska Institutet(Swepub:uu)simce160 (author)
- Collste, KKarolinska Institutet (author)
- Victorsson, PKarolinska Inst, Stockholm, Sweden (author)
- Sellgren, C MKarolinska Institutet (author)
- Flyckt, LKarolinska Institutet (author)
- Erhardt, SKarolinska Institutet (author)
- Engberg, GKarolinska Institutet (author)
- Karolinska InstitutetKarolinska Inst, Stockholm, Sweden (creator_code:org_t)
Related titles
- In:Molecular Psychiatry: Springer Nature23:5, s. 1244-12501359-41841476-5578
Internet link
- https://doi.org/10.1038/mp.2017.25Fulltext
- https://uu.diva-portal.org/smash/get/diva2:1546022/FULLTEXT01.pdffulltext:print
- https://www.nature.com/articles/mp201725.pdf
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440807
- https://doi.org/10.1038/mp.2017.25
- http://kipublications.ki.se/Default.aspx?queryparsed=id:138214059
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- Collste, K
- Victorsson, P
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- Engberg, G
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