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Addition of lenalid...
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Löwenberg, BobErasmus Univ Med Ctr MC, Rotterdam, Netherlands.;Erasmus MC Canc Inst, Rotterdam, Netherlands.
(author)
Addition of lenalidomide to intensive treatment in younger and middle-aged adults with newly diagnosed AML : the HOVON-SAKK-132 trial
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-02-22
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American Society of Hematology,2021
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-440998
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-440998URI
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https://doi.org/10.1182/bloodadvances.2020003855DOI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Lenalidomide, an antineoplastic and immunomodulatory drug, has therapeutic activity in acute myeloid leukemia (AML), but definitive studies about its therapeutic utility have been lacking. In a phase 3 study, we compared 2 induction regimens in newly diagnosed patients age 18 to 65 years with AML: idarubicine-cytarabine (cycle 1) and daunorubicin and intermediate-dose cytarabine (cycle 2) without or with lenalidomide (15 mg orally on days 1-21). One final consolidation cycle of chemotherapy or autologous stem cell transplantation (auto-SCT) or allogeneic SCT (allo-SCT) was provided according to a prognostic risk and minimal residual disease (MRD)-adapted approach. Event-free survival (EFS; primary end point) and other clinical end points were assessed. A second random assignment in patients in complete response or in complete response with incomplete hematologic recovery after cycle 3 or auto-SCT involved 6 cycles of maintenance with lenalidomide (10 mg on days 1-21) or observation. In all, 392 patients were randomly assigned to the control group, and 388 patients were randomly assigned to lenalidomide induction. At a median follow-up of 41 months, the study revealed no differences in outcome between the treatments (EFS, 44% +/- 2% standard error and overall survival, 54% = 2% at 4 years for both arms) although in an exploratory post hoc analysis, a lenalidomide benefit was suggested in SRSF2-mutant AML. In relation to the previous Dutch-Belgian Hemato-Oncology Cooperative Group and Swiss Group for Clinical Cancer Research (HOVON-SAKK) studies that used a similar 3-cycle regimen but did not pursue an MRD-guided approach, these survival estimates compare markedly more favorably. MRD status after cycle 2 lost prognostic value in intermediate-risk AML in the risk-adjusted treatment context. Maintenance with lenalidomide showed no apparent effect on relapse probability in 88 patients randomly assigned for this part of the study.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Pabst, ThomasInselspital Bern, Bern, Switzerland.
(author)
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Maertens, JohanUniv Hosp Gasthuisberg, Leuven, Belgium.
(author)
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Gradowska, PatrycjaErasmus MC Canc Inst, Dutch Belgian Hematooncol Cooperat Grp Data Ctr, Rotterdam, Netherlands.
(author)
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Biemond, Bart J.Amsterdam Univ Med Ctr, Amsterdam, Netherlands.
(author)
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Spertini, OlivierUniv Lausanne UNIL, Lausanne Univ Hosp, Ctr Hosp Univ Vaudois, Lausanne, Switzerland.
(author)
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Vellenga, EdoUniv Groningen, Univ Med Ctr, Groningen, Netherlands.
(author)
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Griskevicius, LaimonasVilnius Univ Hosp, Santaros Klin, Vilnius, Lithuania.;Vilnius Univ, Vilnius, Lithuania.
(author)
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Tick, Lidwine W.Maxima Med Ctr, Eindhoven, Netherlands.
(author)
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Jongen-Lavrencic, MojcaErasmus Univ Med Ctr MC, Rotterdam, Netherlands.;Erasmus MC Canc Inst, Rotterdam, Netherlands.
(author)
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Kooy, Marinus van MarwijkIsala Hosp, Zwolle, Netherlands.
(author)
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Vekemans, Marie-ChristianeUniv Hosp St Luc, Brussels, Belgium.
(author)
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van der Velden, Walter J. F. M.Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands.
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Beverloo, BernaErasmus Univ MC, Dept Clin Genet, Rotterdam, Netherlands.
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Michaux, LucienneKatholieke Univ Leuven, Ctr Human Genet, Leuven, Belgium.;Univ Hosp Leuven, Leuven, Belgium.
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Graux, CarlosUniv Catholique Louvain Namur Godinne, Yvoir, Belgium.
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Deeren, DriesAZ Delta, Roeselare, Belgium.
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de Weerdt, OkkeSt Antonius Hosp, Nieuwegein, Netherlands.
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van Esser, Joost W. J.Amphia Hosp, Breda, Netherlands.
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Bargetzi, MarioKantonsspittal, Aarau, Switzerland.
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Klein, Saskia K.Meander Med Ctr, Amersfoort, Netherlands.
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Gadisseur, AlainUniv Hosp Antwerpen, Edegem, Belgium.
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Westerweel, Peter E.Albert Schweitzer Hosp, Dordrecht, Netherlands.
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Veelken, HendrikUniv Med Ctr, Leiden, Netherlands.
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Gregor, MichaelLuzerner Kantonsspittal, Luzern, Switzerland.
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Silzle, TobiasKantonsspittal, St Gallen, Switzerland.
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Van Lammeren-Venema, DanielleHaga Hosp, The Hague, Netherlands.
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Moors, IneUniv Hosp, Ghent, Belgium.
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Breems, Dimitri A.Ziekenhuis Netwerk Antwerpen, Antwerp, Belgium.
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Hoogendoorn, MelsMed Spectrum Leeuwarden, Leeuwarden, Netherlands.
(author)
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Legdeur, Marie-Cecile J. C.Med Spectrum Twente, Enschede, Netherlands.
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Fischer, ThomasOtto von Guericke Univ Hosp Magdeburg, Magdeburg, Germany.
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Kuball, JuergenUniv Med Ctr Utrecht, Utrecht, Netherlands.
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Cornelissen, JanErasmus Univ Med Ctr MC, Rotterdam, Netherlands.;Erasmus MC Canc Inst, Rotterdam, Netherlands.
(author)
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Porkka, KimmoHelsinki Univ Hosp Canc Ctr, Helsinki, Finland.
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Juliusson, GunnarSkanes Univ Hosp, Lund, Sweden.
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Meyer, PeterStavanger Univ Hosp Rogaland, Stavanger, Norway.
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Höglund, MartinUppsala universitet,Hematologi(Swepub:uu)martinhl
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Gjertsen, Bjorn T.Haukeland Hosp, Bergen, Norway.
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Janssen, Jeroen J. W. M.Amsterdam Vrije Univ, Med Ctr, Amsterdam, Netherlands.
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Huls, GerwinUniv Groningen, Univ Med Ctr, Groningen, Netherlands.
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Passweg, JakobUniv Hosp, Basel, Switzerland.
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Cloos, JacquelineAmsterdam Vrije Univ, Med Ctr, Amsterdam, Netherlands.
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Valk, Peter J. M.Erasmus Univ Med Ctr MC, Rotterdam, Netherlands.;Erasmus MC Canc Inst, Rotterdam, Netherlands.
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van Elssen, Catharina H. M. J.Univ Med Ctr, Maastricht, Netherlands.
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Manz, Markus G.Univ Hosp, Zurich, Switzerland.
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Floisand, YngvarOslo Univ Hosp, Oslo, Norway.
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Ossenkoppele, Gert J.Amsterdam Vrije Univ, Med Ctr, Amsterdam, Netherlands.
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Erasmus Univ Med Ctr MC, Rotterdam, Netherlands.;Erasmus MC Canc Inst, Rotterdam, Netherlands.Inselspital Bern, Bern, Switzerland.
(creator_code:org_t)
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In:Blood Advances: American Society of Hematology5:4, s. 1110-11212473-95292473-9537
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Löwenberg, Bob
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Pabst, Thomas
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Maertens, Johan
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Gradowska, Patry ...
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Biemond, Bart J.
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Spertini, Olivie ...
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Vellenga, Edo
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Griskevicius, La ...
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Tick, Lidwine W.
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Jongen-Lavrencic ...
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Kooy, Marinus va ...
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Vekemans, Marie- ...
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van der Velden, ...
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Beverloo, Berna
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Michaux, Lucienn ...
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Graux, Carlos
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Deeren, Dries
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de Weerdt, Okke
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van Esser, Joost ...
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Bargetzi, Mario
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Klein, Saskia K.
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Gadisseur, Alain
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Westerweel, Pete ...
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Veelken, Hendrik
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Gregor, Michael
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Silzle, Tobias
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Van Lammeren-Ven ...
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Moors, Ine
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Breems, Dimitri ...
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Hoogendoorn, Mel ...
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Legdeur, Marie-C ...
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Fischer, Thomas
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Kuball, Juergen
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Cornelissen, Jan
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Porkka, Kimmo
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Meyer, Peter
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Höglund, Martin
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Gjertsen, Bjorn ...
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Janssen, Jeroen ...
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Huls, Gerwin
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Passweg, Jakob
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Cloos, Jacquelin ...
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Valk, Peter J. M ...
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van Elssen, Cath ...
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Manz, Markus G.
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Ossenkoppele, Ge ...
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