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  • Erlinge, DavidLund University,Lunds universitet,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Molecular Cardiology,Lund University Research Groups,Skåne University Hospital (author)

Identification of vulnerable plaques and patients by intracoronary near-infrared spectroscopy and ultrasound (PROSPECT II) : a prospective natural history study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-441177
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441177URI
  • https://doi.org/10.1016/S0140-6736(21)00249-XDOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-90454URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:146171465URI
  • https://lup.lub.lu.se/record/ab6f4d73-98e4-4877-b599-2000b5969fddURI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Funding Agencies:Abbott Laboratories Infraredx  The Medicines Company 
  • Background: Near-infrared spectroscopy (NIRS) and intravascular ultrasound are promising imaging modalities to identify non-obstructive plaques likely to cause coronary-related events. We aimed to assess whether combined NIRS and intravascular ultrasound can identify high-risk plaques and patients that are at risk for future major adverse cardiac events (MACEs).Methods: PROSPECT II is an investigator-sponsored, multicentre, prospective natural history study done at 14 university hospitals and two community hospitals in Denmark, Norway, and Sweden. We recruited patients of any age with recent (within past 4 weeks) myocardial infarction. After treatment of all flow-limiting coronary lesions, three-vessel imaging was done with a combined NIRS and intravascular ultrasound catheter. Untreated lesions (also known as non-culprit lesions) were identified by intravascular ultrasound and their lipid content was assessed by NIRS. The primary outcome was the covariate-adjusted rate of MACEs (the composite of cardiac death, myocardial infarction, unstable angina, or progressive angina) arising from untreated non-culprit lesions during follow-up. The relations between plaques with high lipid content, large plaque burden, and small lumen areas and patient-level and lesion-level events were determined. This trial is registered with ClinicalTrials.gov, NCT02171065.Findings: Between June 10, 2014, and Dec 20, 2017, 3629 non-culprit lesions were characterised in 898 patients (153 [17%] women, 745 [83%] men; median age 63 [IQR 55-70] years). Median follow-up was 3.7 (IQR 3.0-4.4) years. Adverse events within 4 years occurred in 112 (13.2%, 95% CI 11.0-15.6) of 898 patients, with 66 (8.0%, 95% CI 6.2-10.0) arising from 78 untreated non-culprit lesions (mean baseline angiographic diameter stenosis 46.9% [SD 15.9]). Highly lipidic lesions (851 [24%] of 3500 lesions, present in 520 [59%] of 884 patients) were an independent predictor of patient-level non-culprit lesion-related MACEs (adjusted odds ratio 2.27, 95% CI 1.25-4.13) and nonculprit lesion-specific MACEs (7.83, 4.12-14.89). Large plaque burden (787 [22%] of 3629 lesions, present in 530 [59%] of 898 patients) was also an independent predictor of non-culprit lesion-related MACEs. Lesions with both large plaque burden by intravascular ultrasound and large lipid-rich cores by NIRS had a 4-year non-culprit lesion-related MACE rate of 7.0% (95% CI 4.0-10.0). Patients in whom one or more such lesions were identified had a 4-year non-culprit lesion-related MACE rate of 13.2% (95% CI 9.4-17.6).Interpretation: Combined NIRS and intravascular ultrasound detects angiographically non-obstructive lesions with a high lipid content and large plaque burden that are at increased risk for future adverse cardiac outcomes.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Maehara, AkikoColumbia Univ, Irving Med Ctr, NewYork Presbyterian Hosp, New York, NY USA.;Cardiovasc Res Fdn, New York, NY USA.,NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY, USA; Cardiovascular Research Foundation, New York, NY, USA (author)
  • Ben-Yehuda, OriColumbia Univ, Irving Med Ctr, NewYork Presbyterian Hosp, New York, NY USA.;Cardiovasc Res Fdn, New York, NY USA.;Univ Calif San Diego, San Diego, CA 92103 USA.,NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY, USA; Cardiovascular Research Foundation, New York, NY, USA; University of California San Diego, San Diego, CA, USA (author)
  • Bötker, Hans ErikAarhus Univ Hosp, Aarhus, Denmark.,Aarhus University Hospital, Aarhus, Denmark (author)
  • Maeng, MichaelAarhus Univ Hosp, Aarhus, Denmark.,Aarhus University Hospital, Aarhus, Denmark (author)
  • Kjöller-Hansen, LarsUniv Hosp, Roskilde, Denmark.,Zealand University Hospital, Roskilde, Denmark (author)
  • Engstrøm, ThomasUniv Copenhagen, Copenhagen, Denmark.,University of Copenhagen, Copenhagen, Denmark(Swepub:lu)th4331en (author)
  • Matsumura, MitsuakiCardiovasc Res Fdn, New York, NY USA.,Cardiovascular Research Foundation, New York, NY, USA (author)
  • Crowley, AaronCardiovasc Res Fdn, New York, NY USA.,Cardiovascular Research Foundation, New York, NY, USA (author)
  • Dressler, OvidiuCardiovasc Res Fdn, New York, NY USA.,Cardiovascular Research Foundation, New York, NY, USA (author)
  • Mintz, Gary S.Cardiovasc Res Fdn, New York, NY USA.,Cardiovascular Research Foundation, New York, NY, USA (author)
  • Fröbert, Ole,1964-Örebro University,Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Hlth, Örebro, Sweden.(Swepub:oru)oft (author)
  • Persson, JonasKarolinska Institutet,Danderyd Hospital (author)
  • Wiseth, RuneTrondheim Reg & Univ Hosp, St Olavs Hosp, Trondheim, Norway.,St Olavs Hospital, Trondheim University Hospital, Norway (author)
  • Larsen, Alf IngeStavanger Univ Hosp, Stavanger, Norway.,Stavanger University Hospital, Stavanger, Norway (author)
  • Jensen, Lisette OkkelsOdense Univ Hosp, Odense, Denmark.,Odense University Hospital, Odense, Denmark (author)
  • Nordrehaug, Jan ErikUniv Bergen, Bergen, Norway.,University of Bergen, Bergen, Norway (author)
  • Bleie, ÖyvindHaukeland Hosp, Bergen, Norway.,Haukeland University Hospital, Bergen, Norway (author)
  • Omerovic, ElmirSahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.,Department of Cardiology,Sahlgrenska University Hospital, Gothenburg, Sweden (author)
  • Held, Claes,1956-Uppsala University,Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Kardiologi,Uppsala University and Uppsala Clinical Research Center, Uppsala, Sweden(Swepub:uu)clahe947 (author)
  • James, Stefan,1964-Uppsala University,Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University and Uppsala Clinical Research Center, Uppsala, Sweden(Swepub:uu)stjam367 (author)
  • Ali, Ziad A.Columbia Univ, Irving Med Ctr, NewYork Presbyterian Hosp, New York, NY USA.;Cardiovasc Res Fdn, New York, NY USA.,NewYork-Presbyterian Hospital/Columbia University Irving Medical Center, New York, NY, USA; Cardiovascular Research Foundation, New York, NY, USA (author)
  • Muller, James E.Brigham & Womens Hosp, 75 Francis St, Boston, MA 02115 USA.,Brigham and Women's Hospital, Boston, MA, USA,Brigham and Women's Hospital / Harvard Medical School (author)
  • Stone, Gregg W.Cardiovasc Res Fdn, New York, NY USA.;Icahn Sch Med Mt Sinai, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA.,Cardiovascular Research Foundation, New York, NY, USA; The Zena and Michael A Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA (author)
  • Christersson, ChristinaUppsala universitet,Institutionen för medicinska vetenskaper,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)chchr086 (author)
  • Sarno, GiovannaUppsala universitet,Uppsala kliniska forskningscentrum (UCR),kardiologi(Swepub:uu)giosa853 (author)
  • Molekylär kardiologiForskargrupper vid Lunds universitet (creator_code:org_t)

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  • In:The Lancet: Elsevier397:10278, s. 985-9950140-67361474-547X

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