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Abundantly expresse...
Abundantly expressed class of noncoding RNAs conserved through the multicellular evolution of dictyostelid social amoebas
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- Kjellin, Jonas (author)
- Uppsala universitet,Mikrobiologi och immunologi
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- Avesson, Lotta (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för molekylärbiologi,Department of Molecular Biology,Swedish Univ Agr Sci, Dept Mol Biol, Biomed Ctr, S-75124 Uppsala, Sweden.;Univ Copenhagen, Novo Nordisk Fdn Ctr Prot Res, DK-2200 Copenhagen, Denmark.
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- Reimegård, Johan (author)
- Uppsala universitet,Molekylär evolution,Science for Life Laboratory, SciLifeLab
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- Liao, Zhen, 1983- (author)
- Uppsala Univ, Dept Cell & Mol Biol, S-75124 Uppsala, Sweden.;Swedish Univ Agr Sci, Dept Plant Biol, S-75007 Uppsala, Sweden.,Uppsala University
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- Eichinger, Ludwig (author)
- Univ Cologne, Inst Biochem 1, Med Fac, Ctr Biochem, D-50931 Cologne, Germany.
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- Noegel, Angelika (author)
- Univ Cologne, Inst Biochem 1, Med Fac, Ctr Biochem, D-50931 Cologne, Germany.
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- Glockner, Gernot (author)
- Univ Cologne, Inst Biochem 1, Med Fac, Ctr Biochem, D-50931 Cologne, Germany.
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- Schaap, Pauline (author)
- Univ Dundee, Coll Life Sci, Dundee DD1 5EH, Scotland.
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- Söderbom, Fredrik (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för cell- och molekylärbiologi
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(creator_code:org_t)
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- 2021-01-21
- 2021
- English.
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In: Genome Research. - : Cold Spring Harbor Laboratory Press (CSHL). - 1088-9051 .- 1549-5469. ; 31:3, s. 436-447
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Abstract
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- Aggregative multicellularity has evolved multiple times in diverse groups of eukaryotes, exemplified by the well-studied development of dictyostelid social amoebas, for example, Dictyostelium discoideum. However, it is still poorly understood why multicellularity emerged in these amoebas while the majority of other members of Amoebozoa are unicellular. Previously, a novel type of noncoding RNA, Class I RNAs, was identified in D. discoideum and shown to be important for normal multicellular development. Here, we investigated Class I RNA evolution and its connection to multicellular development. We identified a large number of new Class I RNA genes by constructing a covariance model combined with a scoring system based on conserved upstream sequences. Multiple genes were predicted in representatives of each major group of Dictyostelia and expression analysis confirmed that our search approach identifies expressed Class I RNA genes with high accuracy and sensitivity and that the RNAs are developmentally regulated. Further studies showed that Class I RNAs are ubiquitous in Dictyostelia and share highly conserved structure and sequence motifs. In addition, Class I RNA genes appear to be unique to dictyostelid social amoebas because they could not be identified in outgroup genomes, including their closest known relatives. Our results show that Class I RNA is an ancient class of ncRNAs, likely to have been present in the last common ancestor of Dictyostelia dating back at least 600 million years. Based on previous functional analyses and the presented evolutionary investigation, we hypothesize that Class I RNAs were involved in evolution of multicellularity in Dictyostelia.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Evolutionsbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Evolutionary Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Kjellin, Jonas
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Avesson, Lotta
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Reimegård, Johan
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Liao, Zhen, 1983 ...
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Eichinger, Ludwi ...
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Noegel, Angelika
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show more...
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Glockner, Gernot
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Schaap, Pauline
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Söderbom, Fredri ...
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show less...
- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Evolutionary Bio ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Genome Research
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences