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  • Mino-Kenudson, MariMassachusetts Gen Hosp, Dept Pathol, 55 Fruit St,Warren 122, Boston, MA 02114 USA.;Harvard Med Sch, 55 Fruit St,Warren 122, Boston, MA 02114 USA. (author)

The International Association for the Study of Lung Cancer Global Survey on Programmed Death-Ligand 1 Testing for NSCLC

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • Elsevier,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-442190
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-442190URI
  • https://doi.org/10.1016/j.jtho.2020.12.026DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Introduction: Programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) is required to determine the eligibility for pembrolizumab monotherapy in advanced NSCLC worldwide and for several other indications depending on the country. Four assays have been approved/Communaute Europeene-In vitro Diagnostic (CV-IVD)-marked, but PD-L1 IHC seems diversely implemented across regions and laboratories with the application of laboratory-developed tests (LDTs).Method: To assess the practice of PD-L1 IHC and identify issues and disparities, the International Association for the Study of Lung Cancer Pathology Committee conducted a global survey for pathologists from January to May 2019, comprising multiple questions on preanalytical, analytical, and postanalytical conditions.Result: A total of 344 pathologists from 64 countries participated with 41% from Europe, 24% from North America, and 18% from Asia. Besides biopsies and resections, cellblocks were used by 75% of the participants and smears by 11%. The clone 22C3 was most often used (69%) followed by SP263 (51%). They were applied as an LDT by 40% and 30% of the users, respectively, and 76% of the participants developed at least one LDT. Half of the participants reported a turnaround time of less than or equal to 2 days, whereas 13% reported that of greater than or equal to 5 days. In addition, quality assurance (QA), formal training for scoring, and standardized reporting were not implemented by 18%, 16%, and 14% of the participants, respectively.Conclusions: Heterogeneity in PD-L1 testing is marked across regions and laboratories in terms of antibody clones, IHC assays, samples, turnaround times, and QA measures. The lack of QA, formal training, and standardized reporting stated by a considerable minority identifies a need for additional QA measures and training opportunities.

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  • Le Stang, NolwennCtr Leon Berard Unicanc, Lyon, France. (author)
  • Daigneault, Jillian B.Int Assoc Study Lung Canc, Denver, CO USA. (author)
  • Nicholson, Andrew G.Royal Brompton & Harefield Natl Hlth Serv NHS Fdn, London, England.;Imperial Coll London, Natl Heart & Lung Inst, London, England. (author)
  • Cooper, Wendy A.Royal Prince Alfred Hosp, New South Wales NSW Hlth Pathol, Camperdown, NSW, Australia.;Univ Sydney, Camperdown, NSW, Australia. (author)
  • Roden, Anja C.Mayo Clin, Dept Pathol, Rochester, MN USA. (author)
  • Moreira, Andre L.New York Univ Langone Hlth, Dept Pathol, New York, NY USA. (author)
  • Thunnissen, ErikVrije Univ Amsterdam Med Ctr, Dept Pathol, Amsterdam, Netherlands. (author)
  • Papotti, MauroUniv Turin, Anat Pathol, Turin, Italy. (author)
  • Pelosi, GiuseppeUniv Milan, Dept Oncol & Hematooncol, Milan, Italy.;Ist Ricovero & Cura Carattere Sci IRCCS MultiMed, Milan, Italy. (author)
  • Motoi, NorikoNatl Canc Ctr, Diagnost Pathol, Tokyo, Japan. (author)
  • Poleri, ClaudiaOff Pathol Consultants, Buenos Aires, DF, Argentina. (author)
  • Brambilla, ElisabethUniv Grenoble Alpes, Grenoble, France. (author)
  • Redman, MaryFred Hutchinson Canc Res Ctr, 1124 Columbia St, Seattle, WA 98104 USA. (author)
  • Jain, DeepaliAll India Inst Med Sci, New Delhi, India. (author)
  • Dacic, SanjaUniv Pittsburgh, Med Ctr, Dept Pathol, Pittsburgh, PA USA. (author)
  • Yatabe, YasushiNatl Canc Ctr, Diagnost Pathol, Tokyo, Japan. (author)
  • Tsao, Ming SoundUniv Hlth Network, Princess Margaret Canc Ctr, Toronto, ON, Canada. (author)
  • Lopez-Rios, FernandoHM Hosp, Pathol Lab Dianas Terapeut, Madrid, Spain. (author)
  • Botling, JohanUppsala universitet,Science for Life Laboratory, SciLifeLab,Klinisk och experimentell patologi,Johan Botling(Swepub:uu)johanbot (author)
  • Chen, GangFudan Univ, Zhongshan Hosp, Shanghai, Peoples R China. (author)
  • Chou, Teh-YingTaipei Vet Gen Hosp, Taipei, Taiwan. (author)
  • Hirsch, Fred R.Tisch Canc Inst, Ctr Thorac Oncol, New York, NY USA.;Mt Sinai Hlth Syst, Ichan Sch Med, New York, NY USA. (author)
  • Beasley, Mary BethMt Sinai Hlth Syst, Ichan Sch Med, New York, NY USA. (author)
  • Borczuk, AlainWeill Cornell Med, Dept Pathol, New York, NY USA. (author)
  • Bubendorf, LukasUniv Basel, Inst Pathol, Basel, Switzerland. (author)
  • Chung, Jin-HaengSeoul Natl Univ, Bundang Hosp, Seoul, South Korea. (author)
  • Hwang, DavidSunnybrook Hlth Sci Ctr, Toronto, ON, Canada. (author)
  • Lin, DongmeiPeking Univ Canc Hosp & Inst, Dept Pathol, Beijing, Peoples R China. (author)
  • Longshore, JohnCarolinas Pathol Grp, Charlotte, NC USA. (author)
  • Noguchi, MasayukiUniv Tsukuba, Tsukuba, Ibaraki, Japan. (author)
  • Rekhtman, NatashaMem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA. (author)
  • Sholl, LynetteHarvard Med Sch, 55 Fruit St,Warren 122, Boston, MA 02114 USA.;Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA. (author)
  • Travis, WilliamMem Sloan Kettering Canc Ctr, 1275 York Ave, New York, NY 10021 USA. (author)
  • Yoshida, AkihikoNatl Canc Ctr, Diagnost Pathol, Tokyo, Japan. (author)
  • Wynes, Murry W.Int Assoc Study Lung Canc, Denver, CO USA. (author)
  • Wistuba, Ignacio I.Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA. (author)
  • Kerr, Keith M.Aberdeen Royal Infirm, Dept Pathol, Aberdeen, Scotland. (author)
  • Lantuejoul, SylvieCtr Leon Berard Unicanc, Lyon, France. (author)
  • Massachusetts Gen Hosp, Dept Pathol, 55 Fruit St,Warren 122, Boston, MA 02114 USA.;Harvard Med Sch, 55 Fruit St,Warren 122, Boston, MA 02114 USA.Ctr Leon Berard Unicanc, Lyon, France. (creator_code:org_t)

Related titles

  • In:Journal of Thoracic Oncology: Elsevier16:4, s. 686-6961556-08641556-1380

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