Search: onr:"swepub:oai:DiVA.org:uu-442639" >
Identification of a...
-
Debortoli, GuilhermeDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada
(author)
Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels
- Article/chapterEnglish2021
Publisher, publication year, extent ...
-
2021-01-13
-
Springer Nature,2021
-
electronicrdacarrier
Numbers
-
LIBRIS-ID:oai:DiVA.org:uu-442639
-
https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-442639URI
-
https://doi.org/10.1038/s41598-020-80389-9DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:ref swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographic ancestry and can be used to guide the implementation of PGx clinical decision-support (CDS) tools. We also report that using these panels it is possible to control for the effects of population stratification in association studies in recently admixed populations, as exemplified with a warfarin dosing GWA study in a sample from Brazil.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
de Araujo, Gilderlanio SantanaProgram in Genetics and Molecular Biology, Federal University of Pará, Belém, Brazil
(author)
-
Fortes-Lima, Cesar A.,PhD,1985-Uppsala universitet,Människans evolution(Swepub:uu)cesfo882
(author)
-
Parra, Esteban JDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada
(author)
-
Suarez-Kurtz, GuilhermeInstituto Nacional de Câncer and Rede Nacional de Farmacogenética, Rio de Janeiro, Brazil
(author)
-
Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, CanadaProgram in Genetics and Molecular Biology, Federal University of Pará, Belém, Brazil
(creator_code:org_t)
Related titles
-
In:Scientific Reports: Springer Nature11:12045-2322
Internet link
Find in a library
To the university's database