Identification of ancestry proportions in admixed groups across the Americas using clinical pharmacogenomic SNP panels

Debortoli, GuilhermeDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada (author)

We evaluated the performance of three PGx panels to estimate biogeographical ancestry: the DMET panel, and the VIP and Preemptive PGx panels described in the literature. Our analysis indicate that the three panels capture quite well the individual variation in admixture proportions observed in recently admixed populations throughout the Americas, with the Preemptive PGx and DMET panels performing better than the VIP panel. We show that these panels provide reliable information about biogeographic ancestry and can be used to guide the implementation of PGx clinical decision-support (CDS) tools. We also report that using these panels it is possible to control for the effects of population stratification in association studies in recently admixed populations, as exemplified with a warfarin dosing GWA study in a sample from Brazil.

de Araujo, Gilderlanio SantanaProgram in Genetics and Molecular Biology, Federal University of Pará, Belém, Brazil (author)
Fortes-Lima, Cesar A.,PhD,1985-Uppsala universitet,Människans evolution(Swepub:uu)cesfo882 (author)
Parra, Esteban JDepartment of Anthropology, University of Toronto at Mississauga, Mississauga, ON, Canada (author)
Suarez-Kurtz, GuilhermeInstituto Nacional de Câncer and Rede Nacional de Farmacogenética, Rio de Janeiro, Brazil (author)
Department of Anthropology, University of Toronto at Mississauga, Mississauga, ON, CanadaProgram in Genetics and Molecular Biology, Federal University of Pará, Belém, Brazil (creator_code:org_t)

By the author/editor: Debortoli, Guilh ...; de Araujo, Gilde ...; Fortes-Lima, Ces ...; Parra, Esteban J; Suarez-Kurtz, Gu ...

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NATURAL SCIENCES: NATURAL SCIENCES; and Biological Scien ...; and Evolutionary Bio ...

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