Injectable tricalcium phosphate/calcium sulfate granule enhances bone repair by reversible setting reaction

Cheng, KaiyuanChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China.;Chinese Acad Med Sci & Peking Union Med Coll, 9 Dongdan 3rd Alley, Beijing 100730, Peoples R China. (author)

Towards repairing bone defects, calcium sulfate and calcium phosphate cement have been recognized as promising bone grafts. However, the current bone cements are generally lack of proper porosity for cell migration and new tissue formation. On the other hand, porous scaffold cannot be delivered by injection, which limits its use its clinical use. Herein, we develop a novel tricalcium phosphate/calcium sulfate granule to overcome the limitations of injectable cements and traditional scaffolds. The biocompatible granule underwent in situ self-setting to form scaffold with porous structure after injection. It con-tributes to calcium deposition and upregulation of osteogenic genes of mesenchymal stem cells in a time-dependent manner. Within three months, cavitary bone defects of distal rabbit femurs implanted the granules exhibited better bone formation than those with those implanted with autologous bone.

Zhu, WeiChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China. (author)
Weng, XishengChinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China. (author)
Zhang, LinjieChinese Acad Med Sci & Peking Union Med Coll, 9 Dongdan 3rd Alley, Beijing 100730, Peoples R China. (author)
Yang, LiuUppsala universitet,Tillämpad materialvetenskap,Harbin Inst Technol, Natl Key Lab Sci & Technol Adv Composites Special, Harbin 150001, Peoples R China.(Swepub:uu)liuya610 (author)
Han, ChangChinese Acad Med Sci & Peking Union Med Coll, 9 Dongdan 3rd Alley, Beijing 100730, Peoples R China. (author)
Xia, Wei,Senior Lecture/Associate ProfessorUppsala universitet,Tillämpad materialvetenskap(Swepub:uu)weixi400 (author)
Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China.;Chinese Acad Med Sci & Peking Union Med Coll, 9 Dongdan 3rd Alley, Beijing 100730, Peoples R China.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, 1 Shuaifuyuan, Beijing 100730, Peoples R China. (creator_code:org_t)

In:Biochemical and Biophysical Research Communications - BBRC: Elsevier557, s. 151-1580006-291X1090-2104

By the author/editor: Cheng, Kaiyuan; Zhu, Wei; Weng, Xisheng; Zhang, Linjie; Yang, Liu; Han, Chang; show more...; Xia, Wei, Senior ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Orthopaedics

ENGINEERING AND TECHNOLOGY: ENGINEERING AND ...; and Medical Engineer ...; and Medical Material ...

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