Search: onr:"swepub:oai:DiVA.org:uu-443195" > An integrated multi...
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000 | 12304naa a2200949 4500 | |
001 | oai:DiVA.org:uu-443195 | |
003 | SwePub | |
008 | 210528s2021 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:9097e5ff-635e-4a49-ba63-c7ee9f1bf16e | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4431952 URI |
024 | 7 | a https://doi.org/10.1038/s41467-021-22465-w2 DOI |
024 | 7 | a https://lup.lub.lu.se/record/9097e5ff-635e-4a49-ba63-c7ee9f1bf16e2 URI |
040 | a (SwePub)uud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Viborg Lindskrog, Siau Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut |
245 | 1 0 | a An integrated multi-omics analysis identifies prognostic molecular subtypes of non-muscle-invasive bladder cancer |
264 | c 2021-04-16 | |
264 | 1 | b Springer Nature,c 2021 |
338 | a electronic2 rdacarrier | |
520 | a The molecular landscape in non-muscle-invasive bladder cancer (NMIBC) is characterized by large biological heterogeneity with variable clinical outcomes. Here, we perform an integrative multi-omics analysis of patients diagnosed with NMIBC (n=834). Transcriptomic analysis identifies four classes (1, 2a, 2b and 3) reflecting tumor biology and disease aggressiveness. Both transcriptome-based subtyping and the level of chromosomal instability provide independent prognostic value beyond established prognostic clinicopathological parameters. High chromosomal instability, p53-pathway disruption and APOBEC-related mutations are significantly associated with transcriptomic class 2a and poor outcome. RNA-derived immune cell infiltration is associated with chromosomally unstable tumors and enriched in class 2b. Spatial proteomics analysis confirms the higher infiltration of class 2b tumors and demonstrates an association between higher immune cell infiltration and lower recurrence rates. Finally, the independent prognostic value of the transcriptomic classes is documented in 1228 validation samples using a single sample classification tool. The classifier provides a framework for biomarker discovery and for optimizing treatment and surveillance in next-generation clinical trials. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
700 | 1 | a Prip, Frederiku Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Lamy, Philippeu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Taber, Annu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Groeneveld, Clarice S.u Ligue Natl Canc, Cartes Identite Tumeurs CIT Program, Paris, France; Inst Curie, UMR144, Oncol Mol, Paris, France,Curie Institute, Paris,Ligue Nationale Contre le Cancer4 aut |
700 | 1 | a Birkenkamp-Demtröder, Karinu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Bjerggaard Jensen, Jørgenu Aarhus Univ, Dept Clin Med, Aarhus, Denmark; Aarhus Univ Hosp, Dept Urol, Aarhus N, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Strandgaard, Trineu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Nordentoft, Iveru Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Christensen, Emilu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Sokac, Mateou Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Birkbak, Nicolai J.u Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Maretty, Lasseu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Hermann, Gregers G.u Univ Copenhagen, Herlev Hosp, Dept Urol, Copenhagen, Denmark,University of Copenhagen4 aut |
700 | 1 | a Petersen, Astrid C.u Aalborg Univ Hosp, Dept Pathol, Aalborg, Denmark,Aalborg University Hospital4 aut |
700 | 1 | a Weyerer, Veronikau Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany,University Hospital Erlangen4 aut |
700 | 1 | a Grimm, Marc-Oliveru Jena Univ Hosp, Dept Urol, Jena, Germany,Universitätsklinikum Jena4 aut |
700 | 1 | a Horstmann, Marcusu Jena Univ Hosp, Dept Urol, Jena, Germany; St Josephshosp, Dept Urol, Malteser Hosp, Krefeld, Germany,Universitätsklinikum Jena,St. Josefs Hospital Uerdingen4 aut |
700 | 1 | a Sjödahl, Gottfridu Lund University,Lunds universitet,Urologi - blåscancer, Malmö,Forskargrupper vid Lunds universitet,Genomiska analyser av urinblåscancer,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urology - urothelial cancer, Malmö,Lund University Research Groups,Urothelial Cancer Genomics,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Skane Univ Hosp, Dept Translat Med, Div Urol Res, Malmö, Sweden4 aut0 (Swepub:lu)med-gsj |
700 | 1 | a Höglund, Mattiasu Lund University,Lunds universitet,Genomiska analyser av urinblåscancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Urinblåsecancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Urothelial Cancer Genomics,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Urothelial cancer,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Div Oncol & Pathol, Lund, Sweden4 aut0 (Swepub:lu)kgen-mho |
700 | 1 | a Steiniche, Torbenu Aarhus Univ Hosp, Dept Pathol, Aarhus N, Denmark,Aarhus University Hospital4 aut |
700 | 1 | a Mogensen, Karinu Univ Copenhagen, Herlev Hosp, Dept Urol, Copenhagen, Denmark,University of Copenhagen4 aut |
700 | 1 | a de Reyniès, Aurélienu Ligue Natl Canc, Cartes Identite Tumeurs CIT Program, Paris, France,Ligue Nationale Contre le Cancer4 aut |
700 | 1 | a Nawroth, Romanu Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany4 aut |
700 | 1 | a Jordan, Brianu Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine4 aut |
700 | 1 | a Lin, Xiaoqiu Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine4 aut |
700 | 1 | a Dragicevic, Dejanu Univ Belgrade, Fac Med, Clin Ctr Serbia, Clin Urol, Belgrade, Serbia,University of Belgrade,Leeds School of Medicine,Pennsylvania State University,Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England,Penn State Univ, Dept Surg, Div Urol, Hershey, PA USA4 aut |
700 | 1 | a Ward, Douglas G.u Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham4 aut |
700 | 1 | a Goel, Anshitau Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham4 aut |
700 | 1 | a Hurst, Carolyn D.u Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England4 aut |
700 | 1 | a Raman, Jay D.u Penn State Univ, Dept Surg, Div Urol, Hershey, PA USA4 aut |
700 | 1 | a Warrick, Joshua I.u Penn State Univ, Dept Biochem & Mol Biol, Dept Pathol & Lab Med, Div Urol, Hershey, PA USA,Pennsylvania State University4 aut |
700 | 1 | a Segersten, Ulrikau Uppsala University,Uppsala universitet,Urologkirurgi4 aut0 (Swepub:uu)ulriande |
700 | 1 | a Sikic, Danijelu Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Dept Urol & Pediat Urol, Erlangen, Germany,University Hospital Erlangen4 aut |
700 | 1 | a van Kessel, Kim E. M.u Erasmus MC, Erasmus MC Canc Inst, Dept Pathol, Rotterdam, Netherlands,Erasmus University Medical Center4 aut |
700 | 1 | a Maurer, Tobiasu Tech Univ Munich, Dept Urol, Klinikum Rechts Isar, Munich, Germany; Univ Med Ctr Hamburg Eppendorf, Dept Urol, Hamburg, Germany.;Univ Med Ctr Hamburg Eppendorf, Martini Clin, Hamburg, Germany,University Medical Center Hamburg-Eppendorf4 aut |
700 | 1 | a Meeks, Joshua J.u Northwestern Univ, Sch Med, Dept Pathol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Urol, Chicago, IL 60611 USA.;Northwestern Univ, Sch Med, Dept Biochem, Chicago, IL USA.;Northwestern Univ, Sch Med, Dept Mol Genet, Chicago, IL USA,Northwestern University Feinberg School of Medicine4 aut |
700 | 1 | a DeGraff, David J.u Penn State Univ, Dept Biochem & Mol Biol, Dept Pathol & Lab Med, Div Urol, Hershey, PA USA,Pennsylvania State University4 aut |
700 | 1 | a Bryan, Richard T.u Univ Birmingham, Coll Med & Dent Sci, Bladder Canc Res Ctr, Inst Canc & Genom Sci, Birmingham, W Midlands, England,University of Birmingham4 aut |
700 | 1 | a Knowles, Margaret A.u Univ Leeds, Leeds Inst Med Res St James's, Leeds, W Yorkshire, England,Leeds School of Medicine4 aut |
700 | 1 | a Simic, Tatjanau Univ Belgrade, Fac Med, Inst Med & Clin Biochem, Belgrade, Serbia,University of Belgrade4 aut |
700 | 1 | a Hartmann, Arndtu Friedrich Alexander Univ Erlangen Nuremberg, Univ Hosp Erlangen, Inst Pathol, Erlangen, Germany,University Hospital Erlangen4 aut |
700 | 1 | a Zwarthoff, Ellen C.u Erasmus MC, Erasmus MC Canc Inst, Dept Pathol, Rotterdam, Netherlands,Erasmus University Medical Center4 aut |
700 | 1 | a Malmström, Per-Unou Uppsala University,Uppsala universitet,Urologkirurgi4 aut0 (Swepub:uu)perunoms |
700 | 1 | a Malats, Núriau CIBERONC, Spanish Natl Canc Res Ctr CNIO, Genet & Mol Epidemiol Grp, Madrid, Spain,Spanish National Cancer Research Center (CNIO)4 aut |
700 | 1 | a Real, Francisco X.u Spanish Natl Canc Res Ctr CNIO, Epithelial Carcinogenesis Grp, Madrid, Spain; Univ Pompeu Fabra, Dept Ciencies Expt & Salut, CIBERONC, Barcelona, Spain,Pompeu Fabra University,Spanish National Cancer Research Center (CNIO)4 aut |
700 | 1 | a Dyrskjøt, Larsu Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmark,Aarhus University Hospital4 aut |
710 | 2 | a Aarhus Univ Hosp, Dept Mol Med, Aarhus N, Denmark; Aarhus Univ, Dept Clin Med, Aarhus, Denmarkb Aarhus University Hospital4 org |
773 | 0 | t Nature Communicationsd : Springer Natureg 12:1q 12:1x 2041-1723 |
856 | 4 | u https://doi.org/10.1038/s41467-021-22465-wy Fulltext |
856 | 4 | u https://uu.diva-portal.org/smash/get/diva2:1558085/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/s41467-021-22465-w.pdf |
856 | 4 | u http://dx.doi.org/10.1038/s41467-021-22465-wx freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-443195 |
856 | 4 8 | u https://doi.org/10.1038/s41467-021-22465-w |
856 | 4 8 | u https://lup.lub.lu.se/record/9097e5ff-635e-4a49-ba63-c7ee9f1bf16e |
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