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Learning of nature : The curious case of the naked mole rat
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- Lagunas-Rangel, Francisco Alejandro (author)
- Master in Health Sciences, Graduate Studies Division, Faculty of Biological and Medical Sciences "Dr. Ignacio Chávez", Universidad Michoacana de San Nicolás de Hidalgo, Av. Rafael Carrillo without number, corner with Dr. Salvador González Herrejón, Bosque Cuauhtémoc, 58020, Morelia, Michoacán, Mexico
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- Chávez-Valencia, Venice (author)
- Master in Health Sciences, Graduate Studies Division, Faculty of Biological and Medical Sciences "Dr. Ignacio Chávez", Universidad Michoacana de San Nicolás de Hidalgo, Av. Rafael Carrillo without number, corner with Dr. Salvador González Herrejón, Bosque Cuauhtémoc, 58020, Morelia, Michoacán, Mexico; Nephrology Deparment, Regional General Hospital No. 1, Instituto Mexicano del Seguro Social, Av. Bosques de los Olivos No. 101, Comunidad La Goleta, 61301, Morelia, Michoacán, Mexico
- Master in Health Sciences, Graduate Studies Division, Faculty of Biological and Medical Sciences "Dr Ignacio Chávez", Universidad Michoacana de San Nicolás de Hidalgo, Av. Rafael Carrillo without number, corner with Dr. Salvador González Herrejón, Bosque Cuauhtémoc, 58020, Morelia, Michoacán, Mexico Master in Health Sciences, Graduate Studies Division, Faculty of Biological and Medical Sciences "Dr. Ignacio Chávez", Universidad Michoacana de San Nicolás de Hidalgo, Av. Rafael Carrillo without number, corner with Dr. Salvador González Herrejón, Bosque Cuauhtémoc, 58020, Morelia, Michoacán, Mexico; Nephrology Deparment, Regional General Hospital No. 1, Instituto Mexicano del Seguro Social, Av. Bosques de los Olivos No. 101, Comunidad La Goleta, 61301, Morelia, Michoacán, Mexico (creator_code:org_t)
- Elsevier BV, 2017
- 2017
- English.
- In: Mechanisms of Ageing and Development. - : Elsevier BV. - 0047-6374 .- 1872-6216. ; 164, s. 76-81
- Journal article (peer-reviewed)
Abstract
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- Naked mole rats (NMRs) are the longest-living rodents known, living up to approximately 30 years and showing sustained good health. Nowadays, NMRs are considered excellent models for aging and, additionally, for cancer research, due to the evidence of a remarkable cancer resistance demonstrated through thousands of necropsies performed with very few cases that describe this pathology, which is believed to be a disease that unavoidably accompanies aging. Since some years ago, several studies have tried to explain the possible mechanisms underlying longevity and cancer resistance in NMRs through different perspectives and directions, creating new knowledge that subsequently could be used for cancer prevention and delaying aging in humans. Thus, the purpose of this review is to summarize the recent knowledge on naked mole rats with a particular emphasis on the molecular mechanisms associated with their longevity and cancer resistance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
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