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The transcriptome-wide landscape of molecular subtype-specific mRNA expression profiles in acute myeloid leukemia
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- Mou, Tian (author)
- Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Shenzhen Univ, Sch Biomed Engn, Shenzhen, Peoples R China.
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- Pawitan, Yudi (author)
- Karolinska Institutet,Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Stahl, Matthias (author)
- Karolinska Inst, Dept Oncol Pathol, Sci Life Lab, Stockholm, Sweden.
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- Karolinska Institutet Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden;Shenzhen Univ, Sch Biomed Engn, Shenzhen, Peoples R China. (creator_code:org_t)
- 2021-03-10
- 2021
- English.
- In: American Journal of Hematology. - : John Wiley & Sons. - 0361-8609 .- 1096-8652. ; 96:5, s. 580-588
- Journal article (peer-reviewed)
Abstract
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- Molecular classification of acute myeloid leukemia (AML) aids prognostic stratification and clinical management. Our aim in this study is to identify transcriptome-wide mRNAs that are specific to each of the molecular subtypes of AML. We analyzed RNA-sequencing data of 955 AML samples from three cohorts, including the BeatAML project, the Cancer Genome Atlas, and a cohort of Swedish patients to provide a comprehensive transcriptome-wide view of subtype-specific mRNA expression. We identified 729 subtype-specific mRNAs, discovered in the BeatAML project and validated in the other two cohorts. Using unique proteomics data, we also validated the presence of subtype-specific mRNAs at the protein level, yielding a rich collection of potential protein-based biomarkers for the AML community. To enable the exploration of subtype-specific mRNA expression by the broader scientific community, we provide an interactive resource to the public.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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