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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006635naa a2200841 4500
001oai:DiVA.org:uu-445796
003SwePub
008210617s2021 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4457962 URI
0247 a https://doi.org/10.1016/j.addr.2021.02.0012 DOI
040 a (SwePub)uu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a for2 swepub-publicationtype
1001 a Vinarov, Zahariu Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium; Sofia Univ, Dept Chem & Pharmaceut Engn, Sofia, Bulgaria4 aut
2451 0a Current challenges and future perspectives in oral absorption research :b An opinion of the UNGAP network
264 1b Elsevier,c 2021
338 a electronic2 rdacarrier
520 a Although oral drug delivery is the preferred administration route and has been used for centuries, modern drug discovery and development pipelines challenge conventional formulation approaches and highlight the insufficient mechanistic understanding of processes critical to oral drug absorption. This review presents the opinion of UNGAP scientists on four key themes across the oral absorption landscape: (1) specific patient populations, (2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food-drug interactions. The differences of oral absorption in pediatric and geriatric populations, the specific issues in colonic absorption, the formulation approaches for poorly water-soluble (small molecules) and poorly permeable (peptides, RNA etc.) drugs, as well as the vast realm of food effects, are some of the topics discussed in detail. The identified controversies and gaps in the current understanding of gastrointestinal absorption-related processes are used to create a roadmap for the future of oral drug absorption research.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmaceutiska vetenskaper0 (SwePub)301012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmaceutical Sciences0 (SwePub)301012 hsv//eng
653 a Specific patient populations
653 a Regional differences
653 a Advanced formulations
653 a Amorphous solid dispersions
653 a Lipid-based formulations
653 a Food-drug interactions
653 a Microbiome
653 a In vitro tools
653 a PBPK modeling
7001 a Abrahamsson, Bertilu AstraZeneca, Operat, Pharmaceut Technol & Dev, Oral Prod Dev, Gothenburg, Sweden4 aut
7001 a Artursson, Peru Uppsala universitet,Institutionen för farmaci4 aut0 (Swepub:uu)perartur
7001 a Batchelor, Hannahu Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow, Lanark, Scotland4 aut
7001 a Berben, Philippeu UCB Pharma SA, Pharmaceut Dev, Braine Lalleud, Belgium4 aut
7001 a Bernkop-Schnürch, Andreasu Univ Innsbruck, Inst Pharm, Dept Pharmaceut Technol, Innsbruck, Austria4 aut
7001 a Butler, Jamesu GlaxoSmithKline Res & Dev Ltd, Ware, Herts, England4 aut
7001 a Ceulemans, Jensu Janssen Pharmaceut NV, Beerse, Belgium4 aut
7001 a Davies, Nigelu AstraZeneca, R&D, Pharmaceut Sci, Adv Drug Delivery, Gothenburg, Sweden4 aut
7001 a Dupont, Didieru STLO, Inst Agro, INRAE, Rennes, France4 aut
7001 a Flaten, Gøril Eideu UiT Arctic Univ Norway, Dept Pharm, Tromsø, Norway4 aut
7001 a Fotaki, Nikolettau Univ Bath, Dept Pharm & Pharmacol, Bath, Avon, England4 aut
7001 a Griffin, Brendan T.u Univ Coll Cork, Sch Pharm, Cork, Ireland4 aut
7001 a Jannin, Vincentu Lonza Pharma & Biotech, Colmar, France4 aut
7001 a Keemink, Jannekeu Janssen Pharmaceut NV, Beerse, Belgium4 aut
7001 a Kesisoglou, Filipposu Merck & Co Inc, Pharmaceut Sci, Rahway, NJ 07065 USA4 aut
7001 a Koziolek, Mirkou Abbvie Deutschland GmbH & Co KG, Ludwigshafen, Germany4 aut
7001 a Kuentz, Martinu Univ Appl Sci & Arts Northwestern Switzerland, Inst Pharma Technol, Basel, Switzerland4 aut
7001 a Mackie, Alanu Univ Leeds, Sch Food Sci & Nutr, Leeds, W Yorkshire, England4 aut
7001 a Meléndez-Martínez, Antonio J.u Univ Seville, Food Colour & Qual Lab, Area Nutr & Food Sci, Seville, Spain4 aut
7001 a McAllister, Marku Pfizer PGRD, Drug Prod Design, Sandwich, Kent, England4 aut
7001 a Müllertz, Anetteu Univ Copenhagen, Dept Pharm, Copenhagen, Denmark4 aut
7001 a O'Driscoll, Caitriona M.u Univ Coll Cork, Sch Pharm, Cork, Ireland4 aut
7001 a Parrott, Neilu F Hoffmann La Roche Ltd, Basel, Switzerland4 aut
7001 a Paszkowska, Jadwigau Physiolut Polska Sp Zoo, Wroclaw, Poland4 aut
7001 a Pavek, Petru Charles Univ Prague, Fac Pharm, Hradec Kralove, Czech Republic4 aut
7001 a Porter, Christopher J. H.u Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic, Australia4 aut
7001 a Reppas, Christosu Natl & Kapodistrian Univ Athens, Dept Pharm, Athens, Greece4 aut
7001 a Stillhart, Cordulau F Hoffmann La Roche Ltd, Basel, Switzerland4 aut
7001 a Sugano, Kiyohikou Ritsumeikan Univ, Coll Pharmaceut Sci, Kusatsu, Shiga, Japan4 aut
7001 a Toader, Elenau Univ Med & Pharm Iasi, Fac Med, Iasi, Romania4 aut
7001 a Valentová, Katerinau Czech Acad Sci, Inst Microbiol, Prague, Czech Republic4 aut
7001 a Vertzoni, Mariau Natl & Kapodistrian Univ Athens, Dept Pharm, Athens, Greece4 aut
7001 a De Wildt, Saskia N.u Radboud Univ Nijmegen Med Ctr, Dept Pharmacol & Toxicol, Nijmegen, Netherlands4 aut
7001 a Wilson, Clive G.u Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow, Lanark, Scotland4 aut
7001 a Augustijns, Patricku Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium4 aut
7102 a Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Leuven, Belgium; Sofia Univ, Dept Chem & Pharmaceut Engn, Sofia, Bulgariab AstraZeneca, Operat, Pharmaceut Technol & Dev, Oral Prod Dev, Gothenburg, Sweden4 org
7730 t Advanced Drug Delivery Reviewsd : Elsevierg 171, s. 289-331q 171<289-331x 0169-409Xx 1872-8294
8564 u https://doi.org/10.1016/j.addr.2021.02.001y Fulltext
8564 u https://uu.diva-portal.org/smash/get/diva2:1568382/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u https://doi.org/10.1016/j.addr.2021.02.001
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445796
8564 8u https://doi.org/10.1016/j.addr.2021.02.001

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