[GFR estimation in children - age-adjusted creatinine makes the adult Lund-Malmö equation applicable in children and facilitates automatic GFR reporting from the clinical laboratory]

Nyman, Ulf (author): institutionen för trans-lationell medicin, divisionen för medicinsk radiologi, Lunds universitet, Malmö

Grubb, Anders (author): institutionen för laboratoriemedicin, avdelningen för klinisk kemi och farmakologi, Lunds universitet

Åsling-Monemi, Kajsa (author): enheten för pediatrik, CLINTEC, Karolinska institutet; Astrid Lindgrens barnsjukhus, Stockholm

Björk, Jonas (author): institutionen för laboratoriemedicin, Lunds universitet

(creator_code:org_t)

Läkartidningen Förlag AB, 2021
2021
Swedish.
In: Läkartidningen. - : Läkartidningen Förlag AB. - 0023-7205 .- 1652-7518. ; 118

Related links:: https://urn.kb.se/re...; show more...; http://kipublication...; show less...

Abstract Subject headings

Age-adjustment of creatinine, i.e. recalculation of childhood levels of creatinine to corresponding levels at 18 years of age and applied in the adult revised Lund-Malmö GFR equation led to markedly improved accuracy in Swedish children (n=1 718) at measured GFR <75 mL/min/1.73 m2 (n=318) and preserved high accuracy at ≥75 mL/min/1.73 m2 (n=1 400). The adjusted LMR equation performed as well as dedicated paediatric equations based on height. The proposed adjustment strategy has four strengths: (i) the original coefficients of the adult GFR equation can be used, (ii) the same equation can be used across the entire lifespan without artificial changes in estimated GFR when switching from paediatric to adult care, (iii) the lack of height factor makes it easier to automatically report estimated GFR by the laboratories and (iv) age-adjusted creatinine values imply that well-established creatinine reference intervals for adults can also be used for children.

By the author/editor: Nyman, Ulf; Berg, Ulla; Grubb, Anders; Larsson, Anders; Hansson, Magnus; Littmann, Karin; show more...; Åsling-Monemi, K ...; Björk, Jonas; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Urology and Neph ...

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