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Factor V Leiden Doe...
Factor V Leiden Does Not Modify the Phenotype of Acute Coronary Syndrome or the Extent of Myocardial Necrosis
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- Mahmoodi, Bakhtawar K. (author)
- St Antonius Hosp, Dept Cardiol, Koekoekslaan 1, NL-3435 CM Nieuwegein, Netherlands.;Univ Groningen, UMC Groningen, Dept Hematol, Div Hemostasis & Thrombosis, Groningen, Netherlands.
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- Eriksson, Niclas, 1978- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Klinisk farmakogenomik och osteoporos,Science for Life Laboratory, SciLifeLab
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- Vos, Gerrit J. A. (author)
- St Antonius Hosp, Dept Cardiol, Koekoekslaan 1, NL-3435 CM Nieuwegein, Netherlands.
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- Meijer, Karina (author)
- Univ Groningen, UMC Groningen, Dept Hematol, Div Hemostasis & Thrombosis, Groningen, Netherlands.
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- Siegbahn, Agneta, 1947- (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Institutionen för medicinsk biokemi och mikrobiologi,Koagulation och inflammationsvetenskap,Molekylär epidemiologi,Science for Life Laboratory, SciLifeLab,Kardiologi,Klinisk kemi,Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.;Univ Hosp, Dept Med Sci, Lab Coagulat Res, Clin Chem, Uppsala, Sweden.
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- James, Stefan, 1964- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Institutionen för kirurgiska vetenskaper,Klinisk fysiologi,Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.;Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.
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- Wallentin, Lars, 1943- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Science for Life Laboratory, SciLifeLab,Uppsala Univ, Uppsala Clin Res Ctr, Uppsala, Sweden.;Uppsala Univ, Dept Med Sci, Cardiol, Uppsala, Sweden.
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- ten Berg, Jurrien M. (author)
- St Antonius Hosp, Dept Cardiol, Koekoekslaan 1, NL-3435 CM Nieuwegein, Netherlands.;Cardiovasc Res Inst Maastricht CARIM, Maastricht, Netherlands.
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St Antonius Hosp, Dept Cardiol, Koekoekslaan 1, NL-3435 CM Nieuwegein, Netherlands;Univ Groningen, UMC Groningen, Dept Hematol, Div Hemostasis & Thrombosis, Groningen, Netherlands. Uppsala kliniska forskningscentrum (UCR) (creator_code:org_t)
- John Wiley & Sons, 2021
- 2021
- English.
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In: Journal of the American Heart Association. - : John Wiley & Sons. - 2047-9980. ; 10:11
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https://uu.diva-port... (primary) (Raw object)
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Abstract
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- BACKGROUND: The prothrombotic defect factor V Leiden (FVL) may confer higher risk of ST-segment-elevation myocardial infarction (STEMI), compared with non-ST-segment-elevation acute coronary syndrome, and may be associated with more myocardial necrosis caused by higher thrombotic burden. METHODS AND RESULTS: Patients without history of cardiovascular disease were selected from 2 clinical trials conducted in patients with acute coronary syndrome. FVL was defined as G-to-A substitution at nucleotide 1691 in the factor V (factor V R506Q) gene. Odds ratios were calculated for the association of FVL with STEMI adjusted for age and sex in the overall population and in the subgroups including sex, age (>= 70 versus <70 years), and traditional cardiovascular risk factors. The peak biomarker levels (ie, creatine kinase-myocardial band and high-sensitivity troponin I or T) after STEMI were contrasted between FVL carriers and noncarriers. Because of differences in troponin assays, peak high-sensitivity troponin levels were converted to a ratio scale. The prevalence of FVL mutation was comparable in patients with STEMI (6.0%) and non-ST-segment-elevation acute coronary syndrome (5.8%). The corresponding sex-and age-adjusted odds ratio was 1.06 (95% CI, 0.86-1.30; P=0.59) for the association of FVL with STEMI. Subgroup analysis did not show any differences. In patients with STEMI, neither the median peak creatine kinase-myocardial band nor the peak high-sensitivity troponin ratio showed any differences between wild-type and FVL carriers (P for difference: creatine kinase-myocardial band=0.33; high sensitivity troponin ratio=0.54). CONCLUSIONS: In a general population with acute coronary syndrome, FVL did not discriminate between a STEMI or non-ST-segment-elevation acute coronary syndrome presentation and was unrelated to peak cardiac necrosis markers in patients with STEMI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- cardiovascular disease
- cardiovascular disease risk factors
- coagulation/thrombosis
- factor V Leiden
- genetic polymorphism
Publication and Content Type
- ref (subject category)
- art (subject category)
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Mahmoodi, Bakhta ...
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Eriksson, Niclas ...
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Vos, Gerrit J. A ...
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Meijer, Karina
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Siegbahn, Agneta ...
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James, Stefan, 1 ...
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Wallentin, Lars, ...
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ten Berg, Jurrie ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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Uppsala University