Urinary cytokines correlate with acute kidney injury in critically ill COVID-19 patients

Andersson, Hanna (author): Uppsala universitet,Anestesiologi och intensivvård

Bülow Anderberg, Sara (author): Uppsala universitet,Anestesiologi och intensivvård

Rubertsson, Sten (author): Uppsala universitet,Anestesiologi och intensivvård

Frithiof, Robert (author): Uppsala universitet,Anestesiologi och intensivvård

Hultström, Michael, 1978- (author): Uppsala universitet,Anestesiologi och intensivvård,Integrativ Fysiologi

(creator_code:org_t)

Related links:: https://doi.org/10.1...; show more...; https://uu.diva-port... (primary) (Raw object); https://doi.org/10.1...; https://urn.kb.se/re...; https://doi.org/10.1...; show less...

Abstract Subject headings

BACKGROUND: Acute kidney injury is common in COVID-19 patients admitted to the ICU. Urinary biomarkers are a non-invasive way of assaying renal damage, and so far, urinary cytokines are not fully investigated. The current study aimed to assess urinary cytokine levels in COVID-19 patients.METHODS: Urine was collected from COVID-19 patients (n = 29) in intensive care and compared to a preoperative group of patients (n = 9) with no critical illness. 92 urinary cytokines were analyzed in multiplex using the Olink Target 96 inflammation panel and compared to clinical characteristics, and urinary markers of kidney injury.RESULTS: There were strong correlations between proinflammatory cytokines and between urinary cytokines and urinary kidney injury markers in 29 COVID-19 patients. Several cytokines were correlated to kidney injury, 31 cytokines to AKI stage and 19 cytokines correlated to maximal creatinine.CONCLUSIONS: Urinary inflammatory cytokines from a wide range of immune cell lineages were significantly upregulated during COVID-19 and the upregulation correlated with acute kidney injury as well as urinary markers of kidney tissue damage.

By the author/editor: Gradin, Anna; Andersson, Hanna; Luther, Tomas; Bülow Anderberg, ...; Rubertsson, Sten; Lipcsey, Miklós; show more...; Åberg, Mikael; Larsson, Anders; Frithiof, Robert; Hultström, Micha ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Anesthesiology a ...

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