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Neurocognitive impa...
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Remes, Tiina M.Oulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland; Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
(författare)
Neurocognitive impairment, employment, and social status in radiotherapy-treated adult survivors of childhood brain tumors
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
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2021-01-22
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Oxford University Press,2021
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:uu-448797
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-448797URI
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https://doi.org/10.1093/nop/npab004DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:234055374URI
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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BackgroundLittle is known of the cognitive functions, employment, and social status in adult survivors of childhood brain tumor (BT). We aimed to determine the long-term neurocognitive profile of radiotherapy-treated adult survivors of childhood BT and the relationship between cognitive functions and employment and social status.MethodsNeurocognitive profiles of survivors were assessed in a Finnish national cohort of 71 radiotherapy-treated survivors of childhood BT (median follow-up time: 21 years [range: 5-33 years]) using a cross-sectional design. Neurocognitive outcomes were compared to control (n = 45) and normative values. Tumor- and treatment-related data were collected from the patient files. Information on employment and social status was gathered.ResultsSurvivors’ (median age: 27 years [range: 16-43 years]) median verbal and performance intelligence quotient (IQ) was 90 (range: 49-121) and 87 (range: 43-119), respectively. The cognitive domains with the greatest impairment were executive functions (median z score, −3.5 SD [range: −25.0 to 1.3 SD]), and processing speed and attention (median z score, −2.5 SD [range: −24.9 to 0.5 SD]). Executive functions were associated with employment, educational level, living independently, having an intimate relationship, and having a driving license. Processing speed and attention were related to educational level, living independently, having an intimate relationship, and having a driving license. Performance IQ was associated with educational level and employment status. Working memory was associated with educational level and living independently.ConclusionsRadiotherapy-treated adult survivors of childhood BT experience significant neurocognitive impairment, which is associated with difficulties related to employment and social status.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hovén, EmmaKarolinska Institutet
(författare)
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Ritari, NiinaUniv Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
(författare)
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Pohjasniemi, HeliOulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland
(författare)
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Puosi, RiinaUniv Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
(författare)
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Arikoski, Pekka M.Univ Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland
(författare)
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Arola, Mikko O.Tampere Univ Hosp, Dept Pediat, Tampere, Finland; Univ Tampere, Tampere, Finland
(författare)
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Lähteenmäki, Päivi M.Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland; Turku Univ, Turku, Finland
(författare)
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Lönnqvist, Tuula R. I.Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
(författare)
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Ojaniemi, Marja K.Oulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland
(författare)
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Riikonen, V. PekkaUniv Eastern Finland, Kuopio Univ Hosp, Dept Pediat & Adolescence, Kuopio, Finland
(författare)
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Sirkiä, Kirsti H.Helsinki Univ Hosp, Helsinki, Finland; Univ Helsinki, Dept Pediat & Adolescence, Helsinki, Finland
(författare)
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Winqvist, SatuOulu Univ Hosp, Dept Neurol, Oulu, Finland
(författare)
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Rantala, Heikki M. J.Oulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland
(författare)
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Harila, MarikaOulu Univ Hosp, Dept Neurol, Oulu, Finland
(författare)
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Harila-Saari, Arja H.Uppsala universitet,Barnneurologi/Barnonkologi(Swepub:uu)arjha456
(författare)
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Karolinska InstitutetOulu Univ Hosp, PEDEGO Res Unit, Dept Pediat & Adolescence, Oulu, Finland; Oulu Univ Hosp, Med Res Ctr, Oulu, Finland; Univ Oulu, Oulu, Finland; Univ Helsinki, Childrens Hosp, Dept Child Neurol, Helsinki, Finland; Helsinki Univ Hosp, Helsinki, Finland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Neuro-Oncology Practice: Oxford University Press8:3, s. 266-2772054-25772054-2585
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Till lärosätets databas
- Av författaren/redakt...
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Remes, Tiina M.
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Hovén, Emma
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Ritari, Niina
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Pohjasniemi, Hel ...
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Puosi, Riina
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Arikoski, Pekka ...
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visa fler...
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Arola, Mikko O.
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Lähteenmäki, Päi ...
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Lönnqvist, Tuula ...
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Ojaniemi, Marja ...
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Riikonen, V. Pek ...
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Sirkiä, Kirsti H ...
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Winqvist, Satu
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Rantala, Heikki ...
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Harila, Marika
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Harila-Saari, Ar ...
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Neuro-Oncology P ...
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Uppsala universitet
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Karolinska Institutet