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Neocortex- and hipp...
Neocortex- and hippocampus-specific deletion of Gabrg2 causes temperature-dependent seizures in mice
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- Li, Xinxiao (author)
- Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China; Zhengzhou Univ, Dept Neurosurg, Affiliated Hosp 5, Zhengzhou, Henan, Peoples R China; Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Yinchuan, Ningxia, Peoples R China
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- Guo, Shengnan (author)
- Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China
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- Xu, Siying (author)
- Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China; Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Yinchuan, Ningxia, Peoples R China
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- Chen, Zhangping (author)
- Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China
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- Wang, Lei (author)
- Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China; Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Yinchuan, Ningxia, Peoples R China
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- Ding, Jiangwei (author)
- Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China; Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Yinchuan, Ningxia, Peoples R China
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- Huo, Junming (author)
- Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China
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- Xiao, Lifei (author)
- Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China; Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Yinchuan, Ningxia, Peoples R China
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- He, Zhenquan (author)
- Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China
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- Jin, Zhe (author)
- Uppsala universitet,Institutionen för medicinsk cellbiologi,Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China
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- Wang, Feng (author)
- Zhejiang Univ, Affiliated Hosp 1, Dept Neurosurg, Sch Med, Hangzhou, Zhejiang, Peoples R China
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- Sun, Tao (author)
- Ningxia Med Univ, Ningxia Key Lab Cerebrocranial Dis, Incubat Base Natl Key Lab, Yinchuan, Ningxia, Peoples R China; Ningxia Med Univ, Gen Hosp, Dept Neurosurg, Yinchuan, Ningxia, Peoples R China
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(creator_code:org_t)
- 2021-05-28
- 2021
- English.
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In: Cell Death and Disease. - : Springer Nature. - 2041-4889. ; 12:6
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Abstract
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- Mutations in the GABRG2 gene encoding the γ-aminobutyric acid (GABA) A receptor gamma 2 subunit are associated with genetic epilepsy with febrile seizures plus, febrile seizures plus, febrile seizures, and other symptoms of epilepsy. However, the mechanisms underlying Gabrg2-mediated febrile seizures are poorly understood. Here, we used the Cre/loxP system to generate conditional knockout (CKO) mice with deficient Gabrg2 in the hippocampus and neocortex. Heterozygous CKO mice (Gabrg2fl/wtCre+) exhibited temperature-dependent myoclonic jerks, generalised tonic-clonic seizures, increased anxiety-like symptoms, and a predisposition to induce seizures. Cortical electroencephalography showed the hyperexcitability in response to temperature elevation in Gabrg2fl/wtCre+ mice, but not in wild-type mice. Gabrg2fl/wtCre+ mice exhibited spontaneous seizures and susceptibility to temperature-induced seizures. Loss of neurons were observed in cortical layers V–VI and hippocampus of Gabrg2fl/wtCre+ mice. Furthermore, the latency of temperature- or pentylenetetrazol-induced seizures were significantly decreased in Gabrg2fl/wtCre+ mice compared with wild-type mice. In summary, Gabrg2fl/wtCre+ mice with Gabrg2 deletion in the neocortex and hippocampus reproduce many features of febrile seizures and therefore provide a novel model to further understand this syndrome at the cellular and molecular level.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Li, Xinxiao
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Guo, Shengnan
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Xu, Siying
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Chen, Zhangping
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Wang, Lei
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Ding, Jiangwei
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show more...
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Huo, Junming
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Xiao, Lifei
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He, Zhenquan
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Jin, Zhe
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Wang, Feng
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Sun, Tao
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Cell Death and D ...
- By the university
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Uppsala University