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Impact of hysterect...
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Brunes, M.Karolinska Institutet,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Div Obstet & Gynaecol, S-11883 Stockholm, Sweden.
(author)
Impact of hysterectomy on analgesic, psychoactive and neuroactive drug use in women with endometriosis : nationwide cohort study
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2020-09-06
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John Wiley & Sons,2021
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LIBRIS-ID:oai:DiVA.org:uu-450604
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-450604URI
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https://doi.org/10.1111/1471-0528.16469DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:144582996URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Objective: To evaluate how hysterectomy affects the prescription of analgesic, psychotropic and neuroactive drugs in women with endometriosis using population-based nationwide registers.Design: Nationwide cohort study.Setting: Swedish national registers, from 1 January 2009 to 31 December 2018.Population: Women with benign disease undergoing a total hysterectomy during the 4-year period of 2012-2015. Women with endometriosis (n = 1074) were identified and compared with women who did not have endometriosis (n = 10 890).Methods: Prospectively collected data from two population-based registers were linked: the Swedish National Quality Register of Gynaecological Surgery and the Swedish National Drug Register. Multivariate logistic regression was used as the main statistical method.Main outcome measures: Changes in drug prescription over time for 3 years prior to and 3 years after hysterectomy.Results: The frequency of prescription of analgesics was higher in women with endometriosis compared with women without endometriosis (OR 2.2, 95% CI 1.7-2.9). Among women with endometriosis, the prescription of analgesics (OR 1.0, 95% CI 0.8-1.2) did not decrease 3 years after hysterectomy compared with the 3 years prior to surgery. There was also a significantly higher rate of prescription of psychoactive (OR 1.6, 95% CI 1.4-2.0) and neuroactive drugs (OR 1.9, 95% CI 1.3-2.7) in the long term postoperatively.Conclusions: In women undergoing hysterectomy, endometriosis was associated with a higher prescription rate of analgesics. In the endometriosis group the prescription of analgesic, psychoactive and neuroactive drugs did not decrease when comparing prescription rates for the 3 years prior to and the 3 years after surgery. Tweetable abstract In women with endometriosis, the long-term prescription of analgesics did not decrease after hysterectomy.
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Altman, DanielUppsala universitet,Institutionen för kvinnors och barns hälsa,Stockholm Urogynaecol Clin, Stockholm, Sweden.(Swepub:uu)danal761
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Pålsson, M.Gothenburg Univ, Sahlgrenska Acad, Inst Clin Sci, Dept Obstet & Gynaecol, Gothenburg, Sweden.
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Söderberg, M. W.Karolinska Institutet,Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Div Obstet & Gynaecol, S-11883 Stockholm, Sweden.
(author)
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Ek, M.Karolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Div Obstet & Gynaecol, S-11883 Stockholm, Sweden.
(author)
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Karolinska InstitutetKarolinska Inst, Sodersjukhuset, Dept Clin Sci & Educ, Stockholm, Sweden.;Soder Sjukhuset, Div Obstet & Gynaecol, S-11883 Stockholm, Sweden.
(creator_code:org_t)
Related titles
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In:British Journal of Obstetrics and Gynecology: John Wiley & Sons128:5, s. 846-8551470-03281471-0528
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