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Mapping chromatin a...
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Stepniak, KarolinaPolish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.;Med Univ Gdansk, Int Res Agenda 3P Med Lab, Gdansk, Poland.
(author)
Mapping chromatin accessibility and active regulatory elements reveals pathological mechanisms in human gliomas
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-06-15
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Springer Nature,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-452204
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-452204URI
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https://doi.org/10.1038/s41467-021-23922-2DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Chromatin structure and accessibility, and combinatorial binding of transcription factors to regulatory elements in genomic DNA control transcription. Genetic variations in genes encoding histones, epigenetics-related enzymes or modifiers affect chromatin structure/dynamics and result in alterations in gene expression contributing to cancer development or progression. Gliomas are brain tumors frequently associated with epigenetics-related gene deregulation. We perform whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples to unravel epigenetic dysfunctions driving gliomagenesis. Based on the results of the integrative analysis of the acquired profiles, we create an atlas of active enhancers and promoters in benign and malignant gliomas. We explore these elements and intersect with Hi-C data to uncover molecular mechanisms instructing gene expression in gliomas. Gliomas are tumors often associated with epigenetics-related gene deregulation. Here the authors reveal an atlas of active enhancers and promoters in benign and malignant gliomas by performing whole-genome mapping of chromatin accessibility, histone modifications, DNA methylation patterns and transcriptome analysis simultaneously in multiple tumor samples.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Machnicka, Magdalena A.Univ Warsaw, Fac Math Informat & Mech, Warsaw, Poland.;Med Univ Gdansk, Int Res Agenda 3P Med Lab, Gdansk, Poland.
(author)
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Mieczkowski, JakubPolish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.;Med Univ Gdansk, Int Res Agenda 3P Med Lab, Gdansk, Poland.
(author)
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Macioszek, AnnaUniv Warsaw, Fac Math Informat & Mech, Warsaw, Poland.
(author)
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Wojtas, BartoszPolish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
(author)
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Gielniewski, BartlomiejPolish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
(author)
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Poleszak, KatarzynaPolish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
(author)
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Perycz, MalgorzataPolish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
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Król, Sylwia K.Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
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Guzik, RafalPolish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
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Dabrowski, Michal J.
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Draminski, MichalPolish Acad Sci, Inst Comp Sci, Warsaw, Poland.
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Jardanowska, MartaPolish Acad Sci, Inst Comp Sci, Warsaw, Poland.
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Grabowicz, IlonaPolish Acad Sci, Inst Comp Sci, Warsaw, Poland.
(author)
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Dziedzic, AgataPolish Acad Sci, Inst Comp Sci, Warsaw, Poland.
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Kranas, HannaUniv Warsaw, Fac Math Informat & Mech, Warsaw, Poland
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Sienkiewicz, KarolinaUniv Warsaw, Fac Math Informat & Mech, Warsaw, Poland.
(author)
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Diamanti, Klev,1987-Uppsala universitet,Medicinsk genetik och genomik(Swepub:uu)kledi204
(author)
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Kotulska, KatarzynaChildrens Mem Hlth Inst, Dept Neurol, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neurosurg, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neuropathol, Warsaw, Poland.
(author)
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Grajkowska, WieslawaChildrens Mem Hlth Inst, Dept Neurol, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neurosurg, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neuropathol, Warsaw, Poland.
(author)
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Roszkowski, MarcinChildrens Mem Hlth Inst, Dept Neurol, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neurosurg, Warsaw, Poland.;Childrens Mem Hlth Inst, Dept Neuropathol, Warsaw, Poland.
(author)
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Czernicki, TomaszMed Univ Warsaw, Dept Neurosurg, Warsaw, Poland.
(author)
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Marchel, AndrzejMed Univ Warsaw, Dept Neurosurg, Warsaw, Poland.
(author)
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Komorowski, JanUppsala universitet,Beräkningsbiologi och bioinformatik(Swepub:uu)jakom133
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Kaminska, BozenaPolish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.
(author)
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Wilczynski, BartekUniv Warsaw, Fac Math Informat & Mech, Warsaw, Poland.
(author)
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Polish Acad Sci, Nencki Inst Expt Biol, Warsaw, Poland.;Med Univ Gdansk, Int Res Agenda 3P Med Lab, Gdansk, Poland.Univ Warsaw, Fac Math Informat & Mech, Warsaw, Poland.;Med Univ Gdansk, Int Res Agenda 3P Med Lab, Gdansk, Poland.
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Gielniewski, Bar ...
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Poleszak, Katarz ...
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Draminski, Micha ...
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Grabowicz, Ilona
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Dziedzic, Agata
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Kotulska, Katarz ...
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