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- Elias, Khalid,1975-Uppsala universitet,Gastrointestinalkirurgi (author)
Impact of biliopancreatic diversion with duodenal switch on glucose homeostasis and gut hormones and their correlations with appetite
- Article/chapterEnglish2022
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- Elsevier,2022
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:uu-453519
- https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453519URI
- https://doi.org/10.1016/j.soard.2022.08.010DOI
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- Language:English
- Summary in:English
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- Title in the list of papers in Khalid Elias's thesis: Impact of biliopancreatic diversion with duodenal switch on glucose homeostasis and gut hormones and their correlations to appetite perception
- BackgroundBiliopancreatic diversion with duodenal switch (BPD/DS) results in lifelong changes in gastrointestinal physiology with unclear associations with appetite perception.ObjectiveTo explore mixed meal–induced changes in glucose homeostasis and gut hormones and their correlations with appetite perception.SettingUniversity hospital.MethodsOf 28 patients studied preoperatively (age: 38.4 ± 11.3 years; body mass index [BMI]: 56.5 ± 5.1 kg/m2; 14 women), 19 (68%) returned for postoperative follow-up. Plasma was sampled for 180 minutes during a 260-kcal standardized mixed meal. Concentrations of leptin, glucose, insulin, triglycerides, active acyl-ghrelin, motilin, total glucose-dependent insulinotropic polypeptide (GIP), active glucagon-like peptide 1 (GLP-1), and total peptide YY (PYY) were measured. Subjective appetite sensations were scored.ResultsBPD/DS resulted in 66.1% ± 23.3% excess BMI loss. Leptin was halved. Glucose and insulin levels were reduced, blunting a preoperative peak at 30 minutes, giving a lower homeostasis model assessment for insulin resistance (HOMA-IR; 13.9 versus 4.8). In contrast, reduced ghrelin and motilin concentrations were accompanied by pronounced peaks 20–30 minutes prior to meal responses. GIP was reduced, whereas GLP-1 and PYY responses were markedly increased, with an early postprandial peak (P < .05, for all). HOMA-IR correlated with insulin (r = .72) and GIP (r = .57). Postoperatively, satiety correlated with GLP-1 (r = .56), whereas the gastric motility index correlated with the desire to eat (r = .60), percentage excess BMI loss (r = –.55), and percentage total weight loss (r = –.49). Delta insulin, GLP-1, and leptin correlated positively with percentage total weight loss (r = .51, r = .48, and r = .58, respectively).ConclusionsBPD/DS reduces leptin, HOMA-IR, and GIP while markedly increasing GLP-1 and PYY. This study marks the magnitude change in GLP-1 with additional effects of PYY as important factors for weight loss.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Kirurgi hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Surgery hsv//eng
- gut peptides
- HOMA-IR
- leptin
- biliopancreatic diversion with duodenal switch
- obesity
- Medicinsk vetenskap
- Medical Science
Added entries (persons, corporate bodies, meetings, titles ...)
- Webb, Dominic-LucUppsala universitet,Gastroenterologi/hepatologi(Swepub:uu)domwe127 (author)
- Diaz Tartera, Hetzel O.Uppsala universitet,Gastroenterologi/hepatologi(Swepub:uu)hetdi568 (author)
- Hellström, Per M.,1954-Uppsala universitet,Gastroenterologi/hepatologi(Swepub:uu)perhe742 (author)
- Sundbom, MagnusUppsala universitet,Gastrointestinalkirurgi(Swepub:uu)magsundb (author)
- Uppsala universitetGastrointestinalkirurgi (creator_code:org_t)
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- In:Surgery for Obesity and Related Diseases: Elsevier18:12, s. 1392-13981550-72891878-7533
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