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Functional differen...
Functional differences between TSHR alleles associate with variation in spawning season in Atlantic herring
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- Chen, Junfeng (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Nagoya Univ, Inst Transformat Biomol ITbM, Lab Anim Integrat Physiol, Grad Sch Bioagr Sci, Nagoya, Japan.
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- Bi, Huijuan (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Pettersson, Mats (author)
- Uppsala universitet,Molekylär evolution,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Sato, Daiki (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Tohoku Univ, Grad Sch Life Sci, Sendai, Miyagi, Japan.
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- Fuentes Pardo, Angela P. (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi
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- Mo, Chunheng (author)
- Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Child, Chengdu, Peoples R China.
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- Younis, Shady (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Stanford Univ, Div Immunol & Rheumatol, Stanford, CA 94305 USA.
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- Wallerman, Ola (author)
- Uppsala universitet,Institutionen för genetik och patologi,Medicinsk genetik,Science for Life Laboratory, SciLifeLab,Institutionen för medicinsk biokemi och mikrobiologi,Genomik,Medicinsk genetik och genomik
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- Jern, Patric (author)
- Uppsala universitet,Klinisk virologi,Institutionen för medicinsk biokemi och mikrobiologi,Science for Life Laboratory, SciLifeLab
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- Moles, Gregorio (author)
- CSIC, Dept Fish Physiol & Biotechnol, Inst Acuicultura Torre Sal, Castellon de La Plana, Spain.
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- Gomez, Ana (author)
- CSIC, Dept Fish Physiol & Biotechnol, Inst Acuicultura Torre Sal, Castellon de La Plana, Spain.
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- Kleinau, Gunnar (author)
- Charite, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Inst Med Phys & Biophys CC2, Grp Prot Xray Crystallog & Signal Transduct, Berlin, Germany.
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- Scheerer, Patrick (author)
- Charite, Berlin, Germany.;Free Univ Berlin, Berlin, Germany.;Humboldt Univ, Berlin, Germany.;Inst Med Phys & Biophys CC2, Grp Prot Xray Crystallog & Signal Transduct, Berlin, Germany.
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- Andersson, Leif (author)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Uppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Evolutionsbiologi,Science for Life Laboratory, SciLifeLab,Genomik,Uppsala Univ, Dept Med Biochem & Microbiol, Uppsala, Sweden.;Swedish Univ Agr Sci, Dept Anim Breeding & Genet, Uppsala, Sweden.;Texas A&M Univ, Dept Vet Integrat Biosci, College Stn, TX USA.,Institutionen för husdjursgenetik (HGEN),Department of Animal Breeding and Genetics,Uppsala University,Texas A&M University
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(creator_code:org_t)
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- 2021-06-25
- 2021
- English.
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In: Communications Biology. - : Springer Nature. - 2399-3642. ; 4:1
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Abstract
Subject headings
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- The underlying molecular mechanisms that determine long day versus short day breeders remain unknown in any organism. Atlantic herring provides a unique opportunity to examine the molecular mechanisms involved in reproduction timing, because both spring and autumn spawners exist within the same species. Although our previous whole genome comparisons revealed a strong association of TSHR alleles with spawning seasons, the functional consequences of these variants remain unknown. Here we examined the functional significance of six candidate TSHR mutations strongly associated with herring reproductive seasonality. We show that the L471M missense mutation in the spring-allele causes enhanced cAMP signaling. The best candidate non-coding mutation is a 5.2kb retrotransposon insertion upstream of the TSHR transcription start site, near an open chromatin region, which is likely to affect TSHR expression. The insertion occurred prior to the split between Pacific and Atlantic herring and was lost in the autumn-allele. Our study shows that strongly associated coding and non-coding variants at the TSHR locus may both contribute to the regulation of seasonal reproduction in herring. Junfeng Chen et al. examine potential functional consequences of reproduction timing-associated TSHR alleles segregating in Atlantic herring. By comparing fish that spawn during the spring to those that spawn in the autumn, they find that the spring-allele is correlated with enhanced cAMP signaling and that both coding and non-coding variants in the TSHR locus contribute to seasonal reproduction.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Fisk- och akvakulturforskning (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Fish and Aquacultural Science (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Chen, Junfeng
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Bi, Huijuan
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Pettersson, Mats
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Sato, Daiki
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Fuentes Pardo, A ...
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Mo, Chunheng
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show more...
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Younis, Shady
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Wallerman, Ola
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Jern, Patric
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Moles, Gregorio
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Gomez, Ana
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Kleinau, Gunnar
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Scheerer, Patric ...
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Andersson, Leif
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Biochemistry and ...
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agriculture Fore ...
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and Fish and Aquacul ...
- Articles in the publication
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Communications B ...
- By the university
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Uppsala University
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Swedish University of Agricultural Sciences