Search: onr:"swepub:oai:DiVA.org:uu-454133" >
Effects of endocrin...
Effects of endocrine disruptor furan on reproductive physiology of Sprague Dawley rats : An F1 Extended One-Generation Reproductive Toxicity Study (EOGRTS)
-
- Rehman, Humaira (author)
- Uppsala universitet,Institutionen för neurovetenskap,Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad 44000, Pakistan.
-
- Jahan, S. (author)
- Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad 44000, Pakistan.
-
- Ullah, Imdad (author)
- Uppsala universitet,Institutionen för neurovetenskap
-
show more...
-
- Thörnqvist, Per-Ove (author)
- Uppsala universitet,Winberg: Beteendeneuroendokrinologi
-
- Jabbar, M. (author)
- Univ Gujrat, Dept Stat, Gujrat, Pakistan.
-
- Shoaib, M. (author)
- Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad 44000, Pakistan.
-
- Aman, F. (author)
- Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad 44000, Pakistan.
-
- John, N. (author)
- Quaid I Azam Univ, Fac Biol Sci, Dept Anim Sci, Reprod Physiol Lab, Islamabad 44000, Pakistan.
-
show less...
-
(creator_code:org_t)
- 2020-03-16
- 2020
- English.
-
In: Human and Experimental Toxicology. - : SAGE PUBLICATIONS LTD. - 0960-3271 .- 1477-0903. ; 39:8, s. 1079-1094
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- The present study investigated the reproductive toxicity of furan in an Extended One-Generation Reproductive Toxicity Study in rats. Sprague Dawley F0 weaning rats (30 per sex per group) were exposed to furan orally at 0, 1, 2.5, 5, and 10 mg kg(-1) for 10 weeks (males) and 2 weeks (females) and then mated. Results of F0 indicated that in the furan-treated groups (5 mg kg(-1) and 10 mg kg(-1)), body weight (bw) gain decreased during prebreed and gestational period while increased during lactation periods. F0 animals prebreeding exposure resulted in head tilt and foot splay at 10 mg kg(-1). Number of live pups at birth were decreased (p < 0.001) at 10 mg kg(-1). At postnatal day (PND) 70, a significant (p = 0.03) decrease in testosterone levels of male rats and estrogen levels of female rats (p = 0.05) was observed in 10 mg kg(-1) furan-treated group in F1 generation. Luteinizing hormone, follicle-stimulating hormone, and progesterone levels were also reduced, but their reduction was not statistically significant in all groups. In higher dose furan group (10 mg kg(-1)), testicular and ovarian weights were reduced in F1 generation at PND 70, with decreased daily sperm production (p = 0.01) and disturbed estrous cyclicity (p < 0.01). Some histopathological changes were also observed in testis and ovaries in groups whose parents were previously exposed to 10 mg kg(-1) bw of furan group. Based on the above results, it is suggested that exposure to food-based contaminant furan induced remarkable changes in the F0 (parental stage) and F1 (offspring, pubertal, and adult stage) generations of Sprague Dawley rats.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Furan
- puberty
- Extended One-Generation Reproductive Toxicity Study (EOGRTS)
- histopathology
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database