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  • Wang, RutaoXijing Hosp, Dept Cardiol, Xian, Peoples R China.;Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, Nijmegen, Netherlands. (author)

Impact of chronic obstructive pulmonary disease on 10-year mortality after percutaneous coronary intervention and bypass surgery for complex coronary artery disease : insights from the SYNTAX Extended Survival study

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-03-12
  • Springer Nature,2021
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:uu-454348
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454348URI
  • https://doi.org/10.1007/s00392-021-01833-yDOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • AimsTo evaluate the impact of chronic obstructive pulmonary disease (COPD) on 10-year all-cause death and the treatment effect of CABG versus PCI on 10-year all-cause death in patients with three-vessel disease (3VD) and/or left main coronary artery disease (LMCAD) and COPD.MethodsPatients were stratified according to COPD status and compared with regard to clinical outcomes. Ten-year all-cause death was examined according to the presence of COPD and the revascularization strategy.ResultsCOPD status was available for all randomized 1800 patients, of whom, 154 had COPD (8.6%) at the time of randomization. Regardless of the revascularization strategy, patients with COPD had a higher risk of 10-year all-cause death, compared with those without COPD (43.1% vs. 24.9%; hazard ratio [HR]: 2.03; 95% confidence interval [CI]: 1.56–2.64; p < 0.001). Among patients with COPD, CABG appeared to have a slightly lower risk of 10-year all-cause death compared with PCI (42.3% vs. 43.9%; HR: 0.96; 95% CI: 0.59–1.56, p = 0.858), whereas among those without COPD, CABG had a significantly lower risk of 10-year all-cause death (22.7% vs. 27.1%; HR: 0.81; 95% CI: 0.67–0.99, p = 0.041). There was no significant differential treatment effect of CABG versus PCI on 10-year all-cause death between patients with and without COPD (p interaction = 0.544).ConclusionsCOPD was associated with a higher risk of 10-year all-cause death after revascularization for complex coronary artery disease. The presence of COPD did not significantly modify the beneficial effect of CABG versus PCI on 10-year all-cause death.Trial registration: SYNTAX: ClinicalTrials.gov reference: NCT00114972. SYNTAX Extended Survival: ClinicalTrials.gov reference: NCT03417050

Subject headings and genre

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  • Tomaniak, MariuszMed Univ Warsaw, Dept Cardiol 1, Warsaw, Poland.;Erasmus MC, Dept Cardiol, Rotterdam, Netherlands. (author)
  • Takahashi, KuniakiUniv Amsterdam, Locat Acad Med Ctr, Med Ctr, Dept Cardiol, Amsterdam, Netherlands. (author)
  • Gao, ChaoXijing Hosp, Dept Cardiol, Xian, Peoples R China.;Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, Nijmegen, Netherlands. (author)
  • Kawashima, HideyukiNatl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Univ Amsterdam, Locat Acad Med Ctr, Med Ctr, Dept Cardiol, Amsterdam, Netherlands. (author)
  • Hara, HironoriNatl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Univ Amsterdam, Locat Acad Med Ctr, Med Ctr, Dept Cardiol, Amsterdam, Netherlands. (author)
  • Ono, MasafumiNatl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Univ Amsterdam, Locat Acad Med Ctr, Med Ctr, Dept Cardiol, Amsterdam, Netherlands. (author)
  • van Klaveren, DavidErasmus MC, Dept Publ Hlth, Rotterdam, Netherlands.;Tufts Med Ctr, Inst Clin Res & Hlth Policy Studies, Predict Analyt & Comparat Effectiveness Ctr, Boston, MA 02111 USA. (author)
  • van Geuns, Robert-JanRadboud Univ Nijmegen, Med Ctr, Dept Cardiol, Nijmegen, Netherlands. (author)
  • Morice, Marie-ClaudeICPS Ramsay Gen Sante, Massy, France. (author)
  • Davierwala, Piroze M.Heart Ctr Leipzig, Dept Cardiac Surg, Leipzig, Germany. (author)
  • Mack, Michael J.Baylor Scott & White Hlth, Plano, TX USA. (author)
  • Witkowski, AdamNatl Inst Cardiol, Dept Intervent Cardiol & Angiol, Warsaw, Poland. (author)
  • Curzen, NickUniv Hosp Southampton, Cardiol Dept, Southampton, Hants, England. (author)
  • Berti, SergioFdn CNR Reg Toscana G Monasterio, Heart Hosp, Cardiol Dept, Massa, Italy. (author)
  • Burzotta, FrancescoUniv Cattolica Sacro Cuore, IRCCS, Fdn Policlin Univ Agostino Gemelli, Inst Cardiol, Rome, Italy. (author)
  • James, Stefan,1964-Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)(Swepub:uu)stjam367 (author)
  • Kappetein, Arie PieterErasmus MC, Dept Cardiothorac Surg, Rotterdam, Netherlands. (author)
  • Head, Stuart J.Erasmus MC, Dept Cardiothorac Surg, Rotterdam, Netherlands. (author)
  • Thuijs, Daniel J. F. M.Erasmus MC, Dept Cardiothorac Surg, Rotterdam, Netherlands. (author)
  • Mohr, Friedrich W.Heart Ctr Leipzig, Dept Cardiac Surg, Leipzig, Germany. (author)
  • Holmes, David R.Mayo Clin, Rochester, MN USA. (author)
  • Tao, LingXijing Hosp, Dept Cardiol, Xian, Peoples R China. (author)
  • Onuma, YoshinobuNatl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland. (author)
  • Serruys, Patrick W.Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Imperial Coll London, NHLI, London, England.;Erasmus MC, Rotterdam, Netherlands. (author)
  • Xijing Hosp, Dept Cardiol, Xian, Peoples R China.;Natl Univ Ireland, Galway NUIG, Dept Cardiol, PO Univ Rd, Galway H91 TK33, Ireland.;Radboud Univ Nijmegen, Med Ctr, Dept Cardiol, Nijmegen, Netherlands.Med Univ Warsaw, Dept Cardiol 1, Warsaw, Poland.;Erasmus MC, Dept Cardiol, Rotterdam, Netherlands. (creator_code:org_t)

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  • In:Clinical Research in Cardiology: Springer Nature110:7, s. 1083-10951861-06841861-0692

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