SwePub
Sök i LIBRIS databas

  Extended search

onr:"swepub:oai:DiVA.org:uu-454474"
 

Search: onr:"swepub:oai:DiVA.org:uu-454474" > Genomic insights in...

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist
  • Choin, JeremyInst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.;Univ Paris Diderot, Sorbonne Paris Cite, Paris, France. (author)

Genomic insights into population history and biological adaptation in Oceania

  • Article/chapterEnglish2021

Publisher, publication year, extent ...

  • 2021-04-14
  • Springer Nature,2021
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:uu-454474
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-454474URI
  • https://doi.org/10.1038/s41586-021-03236-5DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • De tre första författarna delar förstaförfattarskapet.De två sista författarna delar sistaförfattarskapet.
  • The Pacific region is of major importance for addressing questions regarding human dispersals, interactions with archaic hominins and natural selection processes(1). However, the demographic and adaptive history of Oceanian populations remains largely uncharacterized. Here we report high-coverage genomes of 317 individuals from 20 populations from the Pacific region. We find that the ancestors of Papuan-related ('Near Oceanian') groups underwent a strong bottleneck before the settlement of the region, and separated around 20,000-40,000 years ago. We infer that the East Asian ancestors of Pacific populations may have diverged from Taiwanese Indigenous peoples before the Neolithic expansion, which is thought to have started from Taiwan around 5,000 years ago(2-4). Additionally, this dispersal was not followed by an immediate, single admixture event with Near Oceanian populations, but involved recurrent episodes of genetic interactions. Our analyses reveal marked differences in the proportion and nature of Denisovan heritage among Pacific groups, suggesting that independent interbreeding with highly structured archaic populations occurred. Furthermore, whereas introgression of Neanderthal genetic information facilitated the adaptation of modern humans related to multiple phenotypes (for example, metabolism, pigmentation and neuronal development), Denisovan introgression was primarily beneficial for immune-related functions. Finally, we report evidence of selective sweeps and polygenic adaptation associated with pathogen exposure and lipid metabolism in the Pacific region, increasing our understanding of the mechanisms of biological adaptation to island environments.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mendoza-Revilla, JavierInst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France. (author)
  • Arauna, Lara R.Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France. (author)
  • Cuadros-Espinoza, SebastianInst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.;Sorbonne Univ, Coll Doctoral, Paris, France. (author)
  • Cassar, OlivierInst Pasteur, CNRS, Oncogen Virus Epidemiol & Pathophysiol, UMR 3569, Paris, France. (author)
  • Larena, MaximilianUppsala universitet,Människans evolution(Swepub:uu)maxla653 (author)
  • Ko, Albert Min-ShanChinese Acad Sci, Inst Vertebrate Paleontol & Paleoanthropol, Key Lab Vertebrate Evolut & Human Origins, Beijing, Peoples R China. (author)
  • Harmant, ChristineInst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France. (author)
  • Laurent, RomainUniv Paris, CNRS, UMR7206, Museum Natl Hist Nat, Paris, France. (author)
  • Verdu, PaulUniv Paris, CNRS, UMR7206, Museum Natl Hist Nat, Paris, France. (author)
  • Laval, GuillaumeInst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France. (author)
  • Boland, AnneUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, Inst Biol Francois Jacob, CEA, Evry, France. (author)
  • Olaso, RobertUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, Inst Biol Francois Jacob, CEA, Evry, France. (author)
  • Deleuze, Jean-FrancoisUniv Paris Saclay, Ctr Natl Rech Genom Humaine CNRGH, Inst Biol Francois Jacob, CEA, Evry, France. (author)
  • Valentin, FrederiqueCNRS, UMR 7041, Maison Archeol & Ethnol, Nanterre, France. (author)
  • Ko, Ying-ChinChina Med Univ & Hosp, Environm Omics Dis Res Ctr, Taichung, Taiwan. (author)
  • Jakobsson, MattiasUppsala universitet,Science for Life Laboratory, SciLifeLab,Människans evolution(Swepub:uu)matja323 (author)
  • Gessain, AntoineInst Pasteur, CNRS, Oncogen Virus Epidemiol & Pathophysiol, UMR 3569, Paris, France. (author)
  • Excoffier, LaurentUniv Bern, Inst Ecol & Evolut, Bern, Switzerland.;Swiss Inst Bioinformat, Lausanne, Switzerland. (author)
  • Stoneking, MarkMax Planck Inst Evolutionary Anthropol, Dept Evolutionary Genet, Leipzig, Germany. (author)
  • Patin, EtienneInst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France. (author)
  • Quintana-Murci, LluisInst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.;Coll France, Paris, France. (author)
  • Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France.;Univ Paris Diderot, Sorbonne Paris Cite, Paris, France.Inst Pasteur, Human Evolutionary Genet Unit, CNRS, UMR 2000, Paris, France. (creator_code:org_t)

Related titles

  • In:Nature: Springer Nature592:7855, s. 583-5890028-08361476-4687

Internet link

Find in a library

  • Nature (Search for host publication in LIBRIS)

To the university's database

  • 1 of 1
  • Previous record
  • Next record
  •    To hitlist

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view