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COVID-19 in solid o...
COVID-19 in solid organ transplant recipients : A national cohort study from Sweden
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- Söfteland, John M., 1977 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Friman, Gustav (author)
- Karolinska Univ Hosp, Dept Transplantat Surg, Stockholm, Sweden.
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- von Zur-Mühlen, Bengt, Docent, 1966- (author)
- Uppsala universitet,Transplantationskirurgi
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- Ericzon, Bo-Göran (author)
- Karolinska Institutet
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- Wallquist, Carin (author)
- Skane Univ Hosp, Dept Nephrol, Malmö, Sweden.
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- Karason, Kristjan (author)
- Sahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden.
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- Friman, Vanda, 1952 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Ekelund, Jan (author)
- Vastra Gotaland, Ctr Registers, Gothenburg, Sweden.
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- Felldin, Marie (author)
- Sahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden.
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- Magnusson, Jesper (author)
- Sahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden.
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- Haugen Löfman, Ida (author)
- Karolinska Univ Hosp, Dept Cardiol, Stockholm, Sweden.
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- Schult, Andreas (author)
- Sahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden.
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- de Coursey, Emily (author)
- Sahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden.
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- Leach, Susannah, 1983 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för mikrobiologi och immunologi,Institute of Biomedicine, Department of Microbiology and Immunology
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- Jacobsson, Hanna (author)
- Sahlgrens Univ Hosp, Transplant Inst, Gothenburg, Sweden.;Sahlgrens Univ Hosp, Biobank West, Gothenburg, Sweden.
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- Liljeqvist, Jan-Åke, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine
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- Biglarnia, Ali R. (author)
- Skane Univ Hosp, Dept Transplantat Surg, Malmö, Sweden.
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- Lindnér, Per, 1956 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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- Oltean, Mihai, 1976 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för kirurgi,Institute of Clinical Sciences, Department of Surgery
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(creator_code:org_t)
- John Wiley & Sons, 2021
- 2021
- English.
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In: American Journal of Transplantation. - : John Wiley & Sons. - 1600-6135 .- 1600-6143. ; 21:8, s. 2762-2773
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Abstract
Subject headings
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- Solid organ transplant (SOT) recipients run a high risk for adverse outcomes from COVID-19, with reported mortality around 19%. We retrospectively reviewed all known Swedish SOT recipients with RT-PCR confirmed COVID-19 between March 1 and November 20, 2020 and analyzed patient characteristics, management, and outcome. We identified 230 patients with a median age of 54.0 years (13.2), who were predominantly male (64%). Most patients were hospitalized (64%), but 36% remained outpatients. Age >50 and male sex were among predictors of transition from outpatient to inpatient status. National early warning Score 2 (NEWS2) at presentation was higher in non-survivors. Thirty-day all-cause mortality was 9.6% (15.0% for inpatients), increased with age and BMI, and was higher in men. Renal function decreased during COVID-19 but recovered in most patients. SARS-CoV-2 antibodies were identified in 78% of patients at 1-2 months post-infection. Nucleocapsid-specific antibodies decreased to 38% after 6-7 months, while spike-specific antibody responses were more durable. Seroprevalence in 559 asymptomatic patients was 1.4%. Many patients can be managed on an outpatient basis aided by risk stratification with age, sex, and NEWS2 score. Factors associated with adverse outcomes include older age, male sex, greater BMI, and a higher NEWS2 score.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- clinical research
- practice
- health services and outcomes research
- immunosuppressant
- infection and infectious agents ‐
- viral
- infectious disease
- kidney (allograft) function
- dysfunction
- organ transplantation in general
- patient characteristics
- patient survival
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Söfteland, John ...
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Friman, Gustav
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von Zur-Mühlen, ...
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Ericzon, Bo-Göra ...
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Wallquist, Carin
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Karason, Kristja ...
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show more...
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Friman, Vanda, 1 ...
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Ekelund, Jan
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Felldin, Marie
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Magnusson, Jespe ...
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Haugen Löfman, I ...
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Schult, Andreas
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de Coursey, Emil ...
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Leach, Susannah, ...
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Jacobsson, Hanna
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Liljeqvist, Jan- ...
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Biglarnia, Ali R ...
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Lindnér, Per, 19 ...
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Oltean, Mihai, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Surgery
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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American Journal ...
- By the university
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Uppsala University
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Karolinska Institutet
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University of Gothenburg