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Implementation of i...
Implementation of iMiDEV™, a new fully automated microfluidic platform for radiopharmaceutical production
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- Ovdiichuk, Olga (author)
- Nancyclotep, Mol Imaging Platform, 5 Rue Morvan, F-54500 Vandoeuvre Les Nancy, France
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- Mallapura, Hemantha (author)
- Karolinska Inst, Dept Clin Neurosci, Ctr Psychiat Res, S-17176 Stockholm, Sweden; Stockholm Cty Council, S-17176 Stockholm, Sweden
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- Pineda, Florian (author)
- PMB Alcen, Route Michels CD56, F-13790 Peynier, France
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- Hourtané, Virginie (author)
- PMB Alcen, Route Michels CD56, F-13790 Peynier, France
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- Långström, Bengt (author)
- Uppsala universitet,Organisk kemi
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- Halldin, Christer (author)
- Karolinska Institutet
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- Nag, Sangram (author)
- Karolinska Institutet
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- Maskali, Fatiha (author)
- Nancyclotep, Mol Imaging Platform, 5 Rue Morvan, F-54500 Vandoeuvre Les Nancy, France
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- Karcher, Gilles (author)
- Nancyclotep, Mol Imaging Platform, 5 Rue Morvan, F-54500 Vandoeuvre Les Nancy, France; CHRU Nancy, Dept Nucl Med, F-54000 Vandoeuvre Les Nancy, France
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- Collet, Charlotte (author)
- Nancyclotep, Mol Imaging Platform, 5 Rue Morvan, F-54500 Vandoeuvre Les Nancy, France; Univ Lorraine, INSERM, U1254 IADI, F-54500 Vandoeuvre Les Nancy, France
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(creator_code:org_t)
- 2021
- 2021
- English.
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In: Lab on a Chip. - : Royal Society of Chemistry. - 1473-0197 .- 1473-0189. ; 21:11, s. 2272-2282
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Abstract
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- iMiDEV™ microfluidic system is a new automated tool for a small-scale production of radiopharmaceuticals. This new radiochemistry module utilizes microfluidic cassettes capable of producing diversified radiopharmaceuticals in liquid phase reactions in an automated synthesizer. The user interface is intuitive and designed to give the operator all the information required and to allow driving the synthesis either manually or fully automatically. In this work, we have demonstrated liquid phase reaction and presented the first results of an efficient fully automated [18F]NaF radiosynthesis on the iMiDEV™ platform. Different parameters such as a type of cyclotron targets, initial activity, concentration and volume of the fluoride-18 targetry have been investigated in order to elaborate the optimised radiolabelling of the ligand. Single and double sodium [18F]fluoride synthesis procedures have been successfully developed using two chambers of the cassette. A single-dose of radiotracer was produced in an average radiochemical yield of 87% (decay corrected) within 8 min and quality control tests were performed as per European Pharmacopoeia.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Ovdiichuk, Olga
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Mallapura, Heman ...
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Pineda, Florian
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Hourtané, Virgin ...
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Långström, Bengt
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Halldin, Christe ...
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show more...
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Nag, Sangram
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Maskali, Fatiha
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Karcher, Gilles
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Collet, Charlott ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
- Articles in the publication
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Lab on a Chip
- By the university
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Uppsala University
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Karolinska Institutet