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Depression and abil...
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Thurin, ErikGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi,Institute of Neuroscience and Physiology
(author)
Depression and ability to work after vestibular schwannoma surgery : a nationwide registry-based matched cohort study on antidepressants, sedatives, and sick leave
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-05-07
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Springer Nature,2021
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:uu-455150
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-455150URI
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https://doi.org/10.1007/s00701-021-04862-8DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:146515593URI
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https://gup.ub.gu.se/publication/304627URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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BackgroundIn patients with vestibular schwannomas (VS), tumor control is often achieved, and life expectancy is relatively good. The main risks of surgical treatment are hearing loss and facial nerve function. The occurrence of mood and sleeping disorders in relation to surgery is an important aspect of health that has rarely been studied. Similarly, only limited data exist on the rate of sick leave for patients with VS. In this nationwide registry-based study, we define the use of antidepressants and sedatives and the sick leave pattern before and after VS surgery.MethodsAdult patients with histopathologically verified VS were identified in the Swedish Brain Tumor Registry (SBTR) and clinical data were linked to relevant national registries after assigning five matched controls to each patient. We studied patterns of dispensed antidepressants and sedative drugs as well as patterns of sick leave compared to respective controls at 2 years before and 2 years following surgery.ResultsWe identified 333 patients and 1662 matched controls. The rate of antidepressant use was similar between patients and controls 2 years before surgery (6.0% vs 6.3%) and 2 years after surgery (10.1% vs 7.5%). The rate of sedative use was also similar 2 years before surgery (3.9% vs 4.3%) and 2 years after surgery (4.8% vs 5.3%). The rate of sick leave was similar at baseline between patients and controls, but at 2 years after surgery, 75% of patients vs 88% of controls (p < 0.01) had no registered sick leave. Long-term sick leave after surgery was predicted by use of sedatives (OR 0.60, 95% CI 0.38–0.94, p = 0.03), more preoperative sick leave (OR 0.91, 95% CI 0.89–0.93, p < 0.001), and new-onset neurological deficits after surgery (OR 0.42, 95% CI 0.24–0.76, p = 0.004).ConclusionThis nationwide study shows no significant differences in the use of antidepressants and sedatives between patients and controls, while the rate of postoperative sick leave was higher in patients than in controls after VS surgery. Our findings underpin the importance of avoiding surgical sequelae and facilitating return to normal professional life.
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Forander, PetterKarolinska Institutet
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Bartek, Jiri, Jr.Karolinska Institutet
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Gulati, SashaSt Olavs Univ Hosp HF, Dept Neurosurg, Postboks 3250 Torgarden, N-7006 Trondheim, Norway.;Norwegian Univ Sci & Technol, Dept Neuromed & Movement Sci, Trondheim, Norway.
(author)
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Rydén, IsabelleGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xrydis
(author)
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Smits, AnjaGothenburg University,Göteborgs universitet,Uppsala universitet,Landtblom: Neurovetenskap,Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Box 430, S-40530 Gothenburg, Sweden,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xsmita
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Hesselager, GöranUppsala universitet,Enblad: Neurokirurgi(Swepub:uu)goranhlr
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Salvesen, OyvindNorwegian Univ Sci & Technol, Dept Publ Hlth & Gen Practice, Trondheim, Norway.
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Jakola, Asgeir StoreGothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience(Swepub:gu)xjakas
(author)
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Göteborgs universitetInstitutionen för neurovetenskap och fysiologi
(creator_code:org_t)
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In:Acta Neurochirurgica: Springer Nature163:8, s. 2225-22350001-62680942-0940
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Thurin, Erik
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Forander, Petter
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Gulati, Sasha
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Smits, Anja
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Uppsala University
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