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Effect of Scalp Coo...
Effect of Scalp Cooling on the Pharmacokinetics of Paclitaxel
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- van Doorn, Leni (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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- van Rosmalen, Mandy M. (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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- van der Deure, Wendy M. (author)
- Groene Hart Hosp, Dept Med Oncol, NL-2803 HH Gouda, Netherlands.
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- Oomen-de Hoop, Esther (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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- Porrazzo, Robert (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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- Wijngaard, Sophie M. (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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- Boere, Ingrid A. (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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- Veenstra, Paola (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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- Ibrahim, Eman (author)
- Uppsala universitet,Institutionen för farmaci
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- de Bruijn, Peter (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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- Friberg, Lena (author)
- Uppsala universitet,Institutionen för farmaci
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- Koolen, Stijn L. W. (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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- Mathijssen, Ron H. J. (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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- Jager, Agnes (author)
- Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands.
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Erasmus MC Canc Inst, Dept Med Oncol, NL-3015 GD Rotterdam, Netherlands Groene Hart Hosp, Dept Med Oncol, NL-2803 HH Gouda, Netherlands. (creator_code:org_t)
- 2021-08-03
- 2021
- English.
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In: Cancers. - : MDPI. - 2072-6694. ; 13:15
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Abstract
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- Simple Summary This study investigated the correlation between scalp cooling used to prevent chemotherapy-induced alopecia and the pharmacokinetics of paclitaxel in female cancer patients with a solid tumor. In a prospective cohort study, 14 patients who were treated with weekly paclitaxel and scalp cooling were able to undergo pharmacokinetic sampling of paclitaxel during one cycle of treatment. In comparison to a control cohort of 24 patients treated with weekly paclitaxel without scalp cooling, our data showed that scalp cooling used concomitantly with one course of paclitaxel did not reduce or increase the clearance of paclitaxel. Therefore, it is unlikely that scalp cooling influences paclitaxel efficacy or toxicity. Finally, despite scalp cooling, half of the patients in our study developed a form of hair loss. Importantly, neither an association with difference in paclitaxel clearance nor change in hair loss was found. Chemotherapy-induced alopecia (CIA), a side effect with high impact, can be prevented by cooling the scalp during the administration of some cytotoxic drugs. However, the effects of this prolonged scalp cooling on the pharmacokinetics of chemotherapy have never been investigated. In this study, we compared the pharmacokinetics of the widely used chemotherapeutic agent paclitaxel (weekly dose of 80-100 mg/m(2)) in female patients with solid tumors using concomitant scalp cooling (n = 14) or not (n = 24). Blood samples were collected in all patients for pharmacokinetic analyses up to 6 h after one course of paclitaxel administration. The primary endpoint was the clearance (L/h) of paclitaxel. Paclitaxel clearance-expressed as relative difference in geometric means-was 6.8% (90% CI: -16.7% to 4.4%) lower when paclitaxel was administered with concomitant scalp cooling versus paclitaxel infusions without scalp cooling. Within the subgroup of patients using scalp cooling, paclitaxel clearance was not statistically significantly different between patients with CIA (alopecia grade 1 or 2) and those without CIA. Hence, scalp cooling did not negatively influence the clearance of paclitaxel treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- chemotherapy-induced alopecia
- scalp cooling
- paclitaxel
- clearance
Publication and Content Type
- ref (subject category)
- art (subject category)
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Cancers
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- By the author/editor
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van Doorn, Leni
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van Rosmalen, Ma ...
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van der Deure, W ...
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Oomen-de Hoop, E ...
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Porrazzo, Robert
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Wijngaard, Sophi ...
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Boere, Ingrid A.
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Veenstra, Paola
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Ibrahim, Eman
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de Bruijn, Peter
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Friberg, Lena
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Koolen, Stijn L. ...
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Mathijssen, Ron ...
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Jager, Agnes
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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Cancers
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Uppsala University