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Metabolomic Profile...
Metabolomic Profile of Abdominal Aortic Aneurysm
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- Lieberg, Juri (author)
- Univ Tartu, Inst Clin Med, Dept Surg, 8 Puusepa St, EE-51014 Tartu, Estonia; Tartu Univ Hosp, Dept Vasc Surg, 8 Puusepa St, EE-51014 Tartu, Estonia
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- Wanhainen, Anders (author)
- Uppsala universitet,Kärlkirurgi
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- Ottas, Aigar (author)
- Univ Tartu, Ctr Excellence Genom & Translat Med, Inst Biomed & Translat Med, Dept Biochem, 19 Ravila St, EE-50411 Tartu, Estonia
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- Vähi, Mare (author)
- Univ Tartu, Inst Math & Stat, 18 Narva Mnt St, EE-51009 Tartu, Estonia
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- Zilmer, Mihkel (author)
- Univ Tartu, Ctr Excellence Genom & Translat Med, Inst Biomed & Translat Med, Dept Biochem, 19 Ravila St, EE-50411 Tartu, Estonia
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- Soomets, Ursel (author)
- Univ Tartu, Ctr Excellence Genom & Translat Med, Inst Biomed & Translat Med, Dept Biochem, 19 Ravila St, EE-50411 Tartu, Estonia
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- Björck, Martin (author)
- Uppsala universitet,Kärlkirurgi
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- Kals, Jaak (author)
- Univ Tartu, Inst Clin Med, Dept Surg, 8 Puusepa St, EE-51014 Tartu, Estonia; Tartu Univ Hosp, Dept Vasc Surg, 8 Puusepa St, EE-51014 Tartu, Estonia; Univ Tartu, Ctr Excellence Genom & Translat Med, Inst Biomed & Translat Med, Dept Biochem, 19 Ravila St, EE-50411 Tartu, Estonia
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(creator_code:org_t)
- 2021-08-22
- 2021
- English.
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In: Metabolites. - : MDPI. - 2218-1989 .- 2218-1989. ; 11:8
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Abstract
Subject headings
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- Abdominal aortic aneurysm (AAA) is characterized by structural deterioration of the aortic wall, leading to aortic dilation and rupture. The aim was to compare 183 low molecular weight metabolites in AAA patients and aorta-healthy controls and to explore if low molecular weight metabolites are linked to AAA growth. Blood samples were collected from male AAA patients with fast (mean 3.3 mm/year; range 1.3–9.4 mm/year; n = 39) and slow growth (0.2 mm/year; range −2.6–1.1 mm/year; n = 40), and from controls with non-aneurysmal aortas (n = 79). Targeted analysis of 183 metabolites in plasma was performed with AbsoluteIDQ p180 kit. The samples were measured on a QTRAP 4500 coupled to an Agilent 1260 series HPLC. The levels of only four amino acids (histidine, asparagine, leucine, isoleucine) and four phosphatidylcholines (PC.ae.C34.3, PC.aa.C34.2, PC.ae.C38.0, lysoPC.a.C18.2) were found to be significantly lower (p < 0.05) after adjustment for confounders among the AAA patients compared with the controls. There were no differences in the metabolites distinguishing the AAA patients with slow or fast growth from the controls, or distinguishing the patients with slow growth from those with fast growth. The current study describes novel significant alterations in amino acids and phosphatidylcholines metabolism associated with AAA occurrence, but no associations were found with AAA growth rate.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- abdominal aortic aneurysm
- biomarkers
- metabolites
- pathophysiology
Publication and Content Type
- ref (subject category)
- art (subject category)
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