Search: onr:"swepub:oai:DiVA.org:uu-456204" >
Association between...
Association between serum markers of the humoral immune system and inflammation in the Swedish AMORIS study
-
- Santaolalla, Aida (author)
- Kings Coll London, Sch Canc & Pharmaceut Sci, Guys Hosp, Translat Oncol & Urol Res TOUR, 3rd Floor, London SE1 9RT, England.
-
- Sollie, Sam (author)
- Kings Coll London, Sch Canc & Pharmaceut Sci, Guys Hosp, Translat Oncol & Urol Res TOUR, 3rd Floor, London SE1 9RT, England.
-
- Rislan, Ali (author)
- Kings Coll London, Sch Canc & Pharmaceut Sci, Guys Hosp, Translat Oncol & Urol Res TOUR, 3rd Floor, London SE1 9RT, England.
-
show more...
-
- Josephs, Debra H. (author)
- Kings Coll London, Sch Canc & Pharmaceut Sci, Guys Hosp, Translat Oncol & Urol Res TOUR, 3rd Floor, London SE1 9RT, England.;Guys & St Thomas NHS Trust, Dept Med Oncol, London, England.
-
- Hammar, Niklas (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Epidemiol Unit, Stockholm, Sweden.
-
- Walldius, Goran (author)
- Karolinska Institutet,Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Stockholm, Sweden.
-
- Garmo, Hans (author)
- Uppsala universitet,Institutionen för kirurgiska vetenskaper,Uppsala Univ Hosp, Reg Canc Ctr, Uppsala, Sweden.
-
- Karagiannis, Sophia N. (author)
- Kings Coll London, St Johns Inst Dermatol, Sch Basic & Med Biosci, Guys Hosp, St John, NF, Canada.;Kings Coll London, Sch Canc & Pharmaceut Sci, Breast Canc Now Res Unit, London, England.
-
- Van Hemelrijck, Mieke (author)
- Kings Coll London, Sch Canc & Pharmaceut Sci, Guys Hosp, Translat Oncol & Urol Res TOUR, 3rd Floor, London SE1 9RT, England.;Karolinska Inst, Inst Environm Med, Unit Cardiovasc Epidemiol, Stockholm, Sweden.
-
show less...
-
Kings Coll London, Sch Canc & Pharmaceut Sci, Guys Hosp, Translat Oncol & Urol Res TOUR, 3rd Floor, London SE1 9RT, England Kings Coll London, Sch Canc & Pharmaceut Sci, Guys Hosp, Translat Oncol & Urol Res TOUR, 3rd Floor, London SE1 9RT, England.;Guys & St Thomas NHS Trust, Dept Med Oncol, London, England. (creator_code:org_t)
- 2021-09-06
- 2021
- English.
-
In: BMC Immunology. - : BioMed Central (BMC). - 1471-2172. ; 22:1
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://bmcimmunol.b...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Background Although the onset of inflammatory cascades may profoundly influence the nature of antibody responses, the interplay between inflammatory and humoral (antibody) immune markers remains unclear. Thus, we explored the reciprocity between the humoral immune system and inflammation and assessed how external socio-demographic factors may influence these interactions. From the AMORIS cohort, 5513 individuals were identified with baseline measurements of serum humoral immune [immunoglobulin G, A & M (IgG, IgA, IgM)] and inflammation (C-reactive protein (CRP), albumin, haptoglobin, white blood cells (WBC), iron and total iron-binding capacity) markers measured on the same day. Correlation analysis, principal component analysis and hierarchical clustering were used to evaluate biomarkers correlation, variation and associations. Multivariate analysis of variance was used to assess associations between biomarkers and educational level, socio-economic status, sex and age. Results Frequently used serum markers for inflammation, CRP, haptoglobin and white blood cells, correlated together. Hierarchical clustering and principal component analysis confirmed the interaction between these main biological responses, showing an acute response component (CRP, Haptoglobin, WBC, IgM) and adaptive response component (Albumin, Iron, TIBC, IgA, IgG). A socioeconomic gradient associated with worse health outcomes was observed, specifically low educational level, older age and male sex were associated with serum levels that indicated infection and inflammation. Conclusions These findings indicate that serum markers of the humoral immune system and inflammation closely interact in response to infection or inflammation. Clustering analysis presented two main immune response components: an acute and an adaptive response, comprising markers of both biological pathways. Future studies should shift from single internal marker assessment to multiple humoral and inflammation serum markers combined, when assessing risk of clinical outcomes such as cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Keyword
- Immune system
- Inflammation
- Biomarkers
- Interaction
- AMORIS
- Multivariable analysis
- Socio economic factors
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database